Abstract 2277: Assessment of the response to STING agonist treatment and potentiation by manganese in glioblastoma cells and the tumor microenvironment
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2277
Abstract: Glioblastoma (GBM) is the most common form of primary malignant brain tumor. Current treatment consists of tumor resection followed by chemoradiotherapy which yields a 5-year survival rate of only 6.8%. The average survival for newly… read more here.
Keywords: response; adu; sting agonist; tumor microenvironment ... See more keywords
Liposomal Delivery of MIW815 (ADU-S100) for Potentiated STING Activation
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DOI: 10.3390/pharmaceutics15020638
Abstract: Stimulator of interferon genes (STING) agonists can improve the anticancer efficacy of immune checkpoint blockade by amplifying tumor immunogenicity. However, the clinical translation of cyclic dinucleotides (CDNs) as STING agonists is hindered by their poor… read more here.
Keywords: delivery; adu; adu s100; sting activation ... See more keywords