Understanding the effects of air pollution on neurogenesis and gliogenesis in the growing and adult brain.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2019.12.003
Abstract: Exposure to air pollution - and particularly to particulate matter (PM) - is strongly associated with higher risk of neurodevelopmental disorders, poor mental health and cognitive defects. In animal models, disruption of CNS development and… read more here.
Keywords: neurogenesis; brain; air pollution; adult brain ... See more keywords
Dicer Deficiency Differentially Impacts Microglia of the Developing and Adult Brain
Sign Up to like & getrecommendations! Published in 2017 at "Immunity"
DOI: 10.1016/j.immuni.2017.05.003
Abstract: Summary Microglia seed the embryonic neuro‐epithelium, expand and actively sculpt neuronal circuits in the developing central nervous system, but eventually adopt relative quiescence and ramified morphology in the adult. Here, we probed the impact of… read more here.
Keywords: adult; dicer; developing adult; microglia developing ... See more keywords
FAM81A protein, a novel component of the postsynaptic density in adult brain
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.02.003
Abstract: Analysis of affinity-purified PSD-95 complexes had previously identified a 'hypothetical protein', product of the gene FAM81A [1]. The present study examined the tissue and subcellular distribution of FAM81A protein and its expression levels during development.… read more here.
Keywords: protein; adult brain; fam81a protein; postsynaptic density ... See more keywords
Development and evaluation of a high resolution 0.5mm isotropic T1-weighted template of the older adult brain
Sign Up to like & getrecommendations! Published in 2022 at "NeuroImage"
DOI: 10.1016/j.neuroimage.2021.118869
Abstract: Investigating the structure of the older adult brain at high spatial resolution is of high significance, and a dedicated older adult structural brain template with sub-millimeter resolution is currently lacking. Therefore, the purpose of this… read more here.
Keywords: adult; template; older adult; resolution ... See more keywords
ATIM-02. A NEW SOURCE OF NEOANTIGENS FOR PEDIATRIC AND ADULT BRAIN CANCER VACCINES
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.002
Abstract: The paucity of mutations in pediatric and adult brain tumors has limited the ability to design therapeutic personal cancer vaccines. However, we have discovered that, in contrast to mutations in DNA, RNA is a rich… read more here.
Keywords: cancer vaccines; pediatric adult; cancer; brain ... See more keywords
Failure of the PTEN/aPKC/Lgl Axis Primes Formation of Adult Brain Tumours in Drosophila
Sign Up to like & getrecommendations! Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/2690187
Abstract: Different regions in the mammalian adult brain contain immature precursors, reinforcing the concept that brain cancers, such as glioblastoma multiforme (GBM), may originate from cells endowed with stem-like properties. Alterations of the tumour suppressor gene… read more here.
Keywords: axis; apkc lgl; pten apkc; brain ... See more keywords
Glial Cells and Their Function in the Adult Brain: A Journey through the History of Their Ablation
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2017.00024
Abstract: Glial cells, consisting of microglia, astrocytes, and oligodendrocyte lineage cells as their major components, constitute a large fraction of the mammalian brain. Originally considered as purely non-functional glue for neurons, decades of research have highlighted… read more here.
Keywords: cell; glial cells; ablation; brain ... See more keywords
Calcium Channels in Adult Brain Neural Stem Cells and in Glioblastoma Stem Cells
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2020.600018
Abstract: The brain of adult mammals, including humans, contains neural stem cells (NSCs) located within specific niches of which the ventricular-subventricular zone (V-SVZ) is the largest one. Under physiological conditions, NSCs proliferate, self-renew and produce new… read more here.
Keywords: adult brain; cells glioblastoma; stem cells; stem ... See more keywords