Haploinsufficiency of Cyfip2 Causes Lithium-Responsive Prefrontal Dysfunction.
Sign Up to like & getrecommendations! Published in 2020 at "Annals of neurology"
DOI: 10.1002/ana.25827
Abstract: OBJECTIVE Genetic variants of the cytoplasmic FMR1-interacting protein 2 (CYFIP2) encoding an actin-regulatory protein are associated with brain disorders, including intellectual disability and epilepsy. However, specific in vivo neuronal defects and potential treatments for CYFIP2-associated… read more here.
Keywords: adult cyfip2; prefrontal dysfunction; lithium responsive; cyfip2 mice ... See more keywords
Altered presynaptic function and number of mitochondria in the medial prefrontal cortex of adult Cyfip2 heterozygous mice
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DOI: 10.1186/s13041-020-00668-4
Abstract: Variants of the cytoplasmic FMR1-interacting protein (CYFIP) gene family, CYFIP1 and CYFIP2, are associated with numerous neurodevelopmental and neuropsychiatric disorders. According to several studies, CYFIP1 regulates the development and function of both pre- and post-synapses… read more here.
Keywords: adult cyfip2; medial prefrontal; cyfip2; mice ... See more keywords