Inherited genetics of adult diffuse glioma and polygenic risk scores-a review.
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-oncology practice"
DOI: 10.1093/nop/npac017
Abstract: Knowledge about inherited and acquired genetics of adult diffuse glioma has expanded significantly over the past decade. Genomewide association studies (GWAS) stratified by histologic subtype identified six germline variants that were associated specifically with glioblastoma… read more here.
Keywords: adult diffuse; diffuse glioma; polygenic risk; risk ... See more keywords
Clinical importance of molecular markers of adult diffuse glioma
Sign Up to like & getrecommendations! Published in 2019 at "Practical Neurology"
DOI: 10.1136/practneurol-2018-002116
Abstract: In 2016, the WHO incorporated molecular markers, in addition to histology, into the diagnostic classification of central nervous system (CNS) tumours. This improves diagnostic accuracy and prognostication: oligo-astrocytoma no longer exists as a clinical entity;… read more here.
Keywords: markers adult; clinical importance; prognosis; adult diffuse ... See more keywords
Adult diffuse intrinsic pontine glioma: clinical, radiological, pathological, molecular features, and treatments of 96 patients.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neurosurgery"
DOI: 10.3171/2022.2.jns211920
Abstract: OBJECTIVE Unlike its pediatric counterpart, adult diffuse intrinsic pontine glioma (DIPG) remains largely unelucidated. In this study, the authors examined the clinical, radiological, pathological, molecular, and clinical aspects of 96 adult DIPGs. METHODS The National… read more here.
Keywords: clinical radiological; adult diffuse; adult; diffuse intrinsic ... See more keywords
Therapeutic Opportunities of Disrupting Genome Integrity in Adult Diffuse Glioma
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DOI: 10.3390/biomedicines10020332
Abstract: Adult diffuse glioma, particularly glioblastoma (GBM), is a devastating tumor of the central nervous system. The existential threat of this disease requires on-going treatment to counteract tumor progression. The present outcome is discouraging as most… read more here.
Keywords: diffuse glioma; tumor; adult diffuse; genome integrity ... See more keywords
Patterns of diagnostic marker assessment in adult diffuse glioma: a survey of the European Confederation of Neuropathological Societies (Euro-CNS)
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Neuropathology"
DOI: 10.5414/np301009
Abstract: The 2016 update of the WHO classification has introduced an integrated diagnostic approach that incorporates both tumor morphology and molecular information. This conceptual change has far-reaching implications, especially for neuropathologists who are in the forefront… read more here.
Keywords: glioma; diffuse glioma; european confederation; adult diffuse ... See more keywords