Benign ovarian thecoma with markedly elevated serum inhibin B levels mimicking adult granulosa cell tumor
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DOI: 10.1016/j.gore.2020.100658
Abstract: Highlights • A rare case of markedly elevated inhibin B associated with an ovarian thecoma.• Inhibin B lacks specificity as a tumor marker for adult granulosa cell tumor.• A full differential for elevated Inhibin B… read more here.
Keywords: ovarian thecoma; adult granulosa; granulosa cell; markedly elevated ... See more keywords
Androgen-secreting adult granulosa cell tumor in a woman with polycystic ovary syndrome: a case report
Sign Up to like & getrecommendations! Published in 2022 at "Gynecological Endocrinology"
DOI: 10.1080/09513590.2022.2143491
Abstract: Abstract Aim: To present the clinicopathologic findings of the second case of androgen-secreting adult granulosa cell tumor (AGCT) in a woman with polycystic ovary syndrome (PCOS) and discuss in the light of the literature. Methods:… read more here.
Keywords: secreting adult; adult granulosa; granulosa cell; case ... See more keywords
Testosterone elevation in ovarian adult granulosa cell tumor: A case report and review of the literature
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DOI: 10.1097/md.0000000000033763
Abstract: Rationale: Adult granulosa cell tumors (AGCT) mainly secret estrogen, but few androgens. It is rarer to have amenorrhea and hyperandrogenemia as clinical features. Here, we report a rare case of right side AGCTs with amenorrhea… read more here.
Keywords: adult granulosa; case; granulosa cell;
Practical roles for molecular diagnostic testing in ovarian adult granulosa cell tumour, Sertoli–Leydig cell tumour, microcystic stromal tumour and their mimics
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DOI: 10.1111/his.13978
Abstract: Within the last decade, molecular advances have provided insights into the genetics of several ovarian sex cord–stromal tumours that have otherwise been enigmatic. Chief among these advances are the identification of FOXL2, DICER1 and CTNNB1… read more here.
Keywords: cell tumour; leydig cell; sertoli leydig; adult granulosa ... See more keywords
P113 Systemic and surgical treatment of adult granulosa cell tumor of the ovary
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2019-esgo.176
Abstract: Introduction/Background Adult granulosa cell tumor (AGCT) are rare non-epithelial ovarian tumors. Main method of treatment is surgical. Role of systemic treatment due to rarity of AGCT and late recurrence still has not determined. Methodology The… read more here.
Keywords: surgical treatment; adult granulosa; granulosa cell; treatment ... See more keywords
P174 Generation of organoids from ovarian adult granulosa cell tumours for individualized drug screening
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2019-esgo.234
Abstract: Introduction/Background Adult granulosa cell tumours (aGCT) constitute a rare subtype of ovarian cancer, with >90% of tumours characterized by the FOXL2 c.402C>G mutation. Recurrences occur in nearly 50% of patients and are associated with a… read more here.
Keywords: adult granulosa; granulosa cell; drug; drug screening ... See more keywords
EP681 Adult granulosa cell tumor associated with peritoneal endometriosis: Is it fair to preserve fertility?
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2019-esgo.735
Abstract: Introduction/Background The adult granulosa cell tumor (GCT) is derived from ovarian sex-cord stromal cells in the ovaries. It is a rare type of cancer, which accounts for 2–5% of all cases of ovarian carcinoma and… read more here.
Keywords: endometriosis; tumor; adult; adult granulosa ... See more keywords
Abstract 1617: TGFBR1 as a novel therapeutic target in adult granulosa cell tumors
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DOI: 10.1158/1538-7445.am2023-1617
Abstract: Adult granulosa cell tumor (AGCT) is a subtype of sex-cord stromal tumors and accounts for ~5% of all ovarian neoplasms. Nearly 100% of AGCT cases are caused by an oncogenic point mutation in the Forkhead… read more here.
Keywords: kgn cells; cell; adult granulosa; granulosa cell ... See more keywords
Mutational Landscape of Ovarian Adult Granulosa Cell Tumors from Whole Exome and Targeted TERT Promoter Sequencing
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DOI: 10.1158/1541-7786.mcr-18-0359
Abstract: Adult granulosa cell tumor (aGCT), the most common malignant ovarian sex cord-stromal tumor, is characterized by the forkhead transcription factor FOXL2 p.C134W somatic mutation. Late recurrences are relatively common but the molecular mechanisms of relapse… read more here.
Keywords: mutational landscape; adult granulosa; tert promoter; promoter ... See more keywords
Is adjuvant chemotherapy beneficial for patients with FIGO stage IC adult granulosa cell tumor of the ovary?
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DOI: 10.1186/s13048-018-0396-x
Abstract: BackgroundTo evaluate the association between adjuvant chemotherapy and clinical outcomes in patients with stage IC adult granulosa cell tumor (AGCT).MethodsWe performed a retrospective study of patients with stage IC AGCT diagnosed at our hospital from… read more here.
Keywords: chemotherapy; adjuvant chemotherapy; adult granulosa; granulosa cell ... See more keywords