Regulatory pathways governing murine coronary vessel formation are dysregulated in the injured adult heart
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10710-2
Abstract: The survival of ischaemic cardiomyocytes after myocardial infarction (MI) depends on the formation of new blood vessels. However, endogenous neovascularization is inefficient and the regulatory pathways directing coronary vessel growth are not well understood. Here… read more here.
Keywords: adult; coronary vessel; vessel; regulatory pathways ... See more keywords
Exploring the interactions between cardiomyocytes and endothelial cells to induce cardiac revascularization and regeneration
Sign Up to like & getrecommendations! Published in 2024 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvae088.061
Abstract: None. The adult heart is unable to regenerate after ischemic injury, primarily due to the incapacity of cardiomyocyte (CM) to re-enter in the cell cycle and endothelial cells (EC) to form new vessels. Interestingly, our… read more here.
Keywords: differentiation; adult heart; adult; proliferation ... See more keywords
The 2018 adult heart allocation policy change benefits low‐volume transplant centers
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DOI: 10.1111/ctr.14389
Abstract: The effect of the 2018 adult heart allocation policy change at an institution‐level remains unclear. The present study assessed the impact of the policy change by transplant center volume. read more here.
Keywords: 2018 adult; policy; policy change; adult heart ... See more keywords
Abstract Fri170: Mechanosensitive Role of RBFOX2 in Congenital vs Adult Heart Diseases
Sign Up to like & getrecommendations! Published in 2025 at "Circulation Research"
DOI: 10.1161/res.137.suppl_1.fri170
Abstract: Background: RBFOX2 is an RNA binding protein that regulates alternative splicing (AS) of pre-mRNA transcripts and in turn, generation of different mRNA and protein isoforms. RBFOX2 is implicated in adult and congenital heart diseases. Dysregulation… read more here.
Keywords: adult heart; role; rbfox2; heart ... See more keywords
Abstract Thu031: MCM2 overexpression in the adult heart promotes cardiac rejuvenation and protection after infarction.
Sign Up to like & getrecommendations! Published in 2025 at "Circulation Research"
DOI: 10.1161/res.137.suppl_1.thu031
Abstract: Background: Recent studies demonstrate that promoting cell cycle reentry in adult cardiomyocytes (CM) enhances cardiac rejuvenation by influencing paracrine signaling. We previously demonstrated that the inhibition of two cell cycle inhibitors, Retinoblastoma 1 ( Rb1… read more here.
Keywords: cardiac rejuvenation; adult heart; adult; mcm2 ... See more keywords
Endothelial EphB4 maintains vascular integrity and transport function in adult heart
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DOI: 10.7554/elife.45863
Abstract: The homeostasis of heart and other organs relies on the appropriate provision of nutrients and functional specialization of the local vasculature. Here, we have used mouse genetics, imaging and cell biology approaches to investigate how… read more here.
Keywords: endothelial ephb4; ephb4 maintains; adult heart; heart ... See more keywords