Glial progenitor cells of the adult human white and grey matter are contextually distinct
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24291
Abstract: Genomic analyses have revealed heterogeneity among glial progenitor cells (GPCs), but the compartment selectivity of human GPCs (hGPCs) is unclear. Here, we asked if GPCs of human grey and white brain matter are distinct in… read more here.
Keywords: matter; white matter; progenitor cells; glial progenitor ... See more keywords
Sexual Dimorphisms in Adult Human Brown Adipose Tissue
Sign Up to like & getrecommendations! Published in 2020 at "Obesity"
DOI: 10.1002/oby.22698
Abstract: This study aimed to quantify and compare the amount, activity, and anatomical distribution of cold‐activated brown adipose tissue (BAT) in healthy, young, lean women and men. read more here.
Keywords: dimorphisms adult; adult human; sexual dimorphisms; adipose tissue ... See more keywords
Serum‐free bioprocessing of adult human and rodent skin‐derived Schwann cells: implications for cell therapy in nervous system injury
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2252
Abstract: Peripheral nerve injury affects 2.8% of trauma patients with severe cases often resulting in long‐lived permanent disability, despite nerve repair surgery. Autologous Schwann cell (SC) therapy currently provides an exciting avenue for improved outcomes for… read more here.
Keywords: adult; skin derived; adult human; cell therapy ... See more keywords
Attenuation of PRRX2 and HEY2 enables efficient conversion of adult human skin fibroblasts to neurons.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.06.089
Abstract: The direct conversion of accessible cells such as human fibroblasts to inaccessible cells, particularly neurons, opens up many opportunities for using the human model system to study diseases and discover therapies. Previous studies have indicated… read more here.
Keywords: hey2; adult human; human skin; conversion ... See more keywords
Heparanase is expressed in adult human osteoarthritic cartilage and drives catabolic responses in primary chondrocytes.
Sign Up to like & getrecommendations! Published in 2018 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2018.05.013
Abstract: OBJECTIVES The chondrocytes' pericellular matrix acts as a mechanosensor by sequestering growth factors that are bound to heparan sulfate (HS) proteoglycans. Heparanase is the sole mammalian enzyme with HS degrading endoglycosidase activity. Here, we aimed… read more here.
Keywords: heparanase; primary chondrocytes; adult human; osteoarthritic cartilage ... See more keywords
Thyrotropin regulation of differentiated gene transcription in adult human thyrocytes in primary culture
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2020.111032
Abstract: Thyroid transcription factors (TTFs) - NKX2-1, FOXE1, PAX8 and HHEX - regulate multiple genes involved in thyroid development in mice but little is known about TTF regulation of thyroid-specific genes - thyroglobulin (TG), thyroid peroxidase… read more here.
Keywords: transcription; adult human; thyroid specific; human thyrocytes ... See more keywords
Adult Human Hippocampal Neurogenesis: Controversy and Evidence.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2018.04.002
Abstract: The hippocampus has been described as one of the few sites in the mammalian brain capable of generating new cells continuously throughout life. Two recent studies that report contradicting findings on adult human hippocampal neurogenesis,… read more here.
Keywords: adult human; hippocampal neurogenesis; human hippocampal; neurogenesis controversy ... See more keywords
Adult Human Glioblastomas Harbor Radial Glia-like Cells
Sign Up to like & getrecommendations! Published in 2020 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2020.01.007
Abstract: Summary Radial glia (RG) cells are the first neural stem cells to appear during embryonic development. Adult human glioblastomas harbor a subpopulation of RG-like cells with typical RG morphology and markers. The cells exhibit the… read more here.
Keywords: radial glia; human glioblastomas; adult human; like cells ... See more keywords
Notochordal and nucleus pulposus marker expression is maintained by sub-populations of adult human nucleus pulposus cells through aging and degeneration
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-01567-w
Abstract: The nucleus pulposus (NP) of the intervertebral disc (IVD) demonstrates substantial changes in cell and matrix composition with both ageing and degeneration. While recent transcriptomic profiling studies have helped define human NP cell phenotype, it… read more here.
Keywords: adult human; marker; pulposus; expression ... See more keywords
Molecular characteristics and spatial distribution of adult human corneal cell subtypes
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-94933-8
Abstract: Bulk RNA sequencing of a tissue captures the gene expression profile from all cell types combined. Single-cell RNA sequencing identifies discrete cell-signatures based on transcriptomic identities. Six adult human corneas were processed for single-cell RNAseq… read more here.
Keywords: single cell; corneal; adult human; molecular characteristics ... See more keywords
Small Molecules Enhance Reprogramming of Adult Human Dermal Fibroblasts to Dorsal Forebrain Precursor Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Stem cells and development"
DOI: 10.1089/scd.2021.0130
Abstract: The development of human cell-based platforms for disease modelling, drug discovery and regenerative therapy rely on robust and practical methods to derive high yields of relevant neuronal subtypes. Direct reprogramming strategies have sought to provide… read more here.
Keywords: dorsal forebrain; precursor; adult human; cell ... See more keywords