Daily, limited access to methamphetamine self-administration during pregnancy leads to increased methamphetamine sensitivity in adult offspring.
Sign Up to like & getrecommendations! Published in 2022 at "Developmental psychobiology"
DOI: 10.1002/dev.22350
Abstract: Methamphetamine use by women, even throughout pregnancy, is common. But there is limited knowledge about the effects in prenatally methamphetamine-exposed children. This study investigated how prenatal methamphetamine exposure in rats, via maternal i.v. self-administration, affected… read more here.
Keywords: self administration; methamphetamine; methamphetamine self; adult offspring ... See more keywords
Maternal hypothyroidism in mice influences glucose metabolism in adult offspring
Sign Up to like & getrecommendations! Published in 2020 at "Diabetologia"
DOI: 10.1007/s00125-020-05172-x
Abstract: During pregnancy, maternal metabolic disease and hormonal imbalance may alter fetal beta cell development and/or proliferation, thus leading to an increased risk for developing type 2 diabetes in adulthood. Although thyroid hormones play an important… read more here.
Keywords: hypothyroidism; adult; maternal hypothyroidism; adult offspring ... See more keywords
The Evaluation of Folic Acid-Deficient or Folic Acid-Supplemented Diet in the Gestational Phase of Female Rats and in Their Adult Offspring Subjected to an Animal Model of Schizophrenia
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0493-7
Abstract: Although folic acid (FA) supplementation is known to influence numerous physiological functions, especially during pregnancy, little is known about its direct effects on the mothers’ health. However, this vitamin is essential for the health of… read more here.
Keywords: folic acid; animal model; adult offspring; effect ... See more keywords
Maternal endotoxemia induces renal collagen deposition in adult offspring: Role of NADPH oxidase/TGF-β1/MMP-2 signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2020.108306
Abstract: Maternal endotoxemia has been shown to increase renal collagen deposition in the offspring. Renal fibrosis is a hallmark of progressive chronic kidney disease. It was investigated whether maternal reactive oxygen species (ROS) leads to renal… read more here.
Keywords: collagen; collagen deposition; maternal endotoxemia; adult offspring ... See more keywords
Clinical phenotype of adult offspring carriers of the p.Pro392Leu mutation within the SQSTM1 gene in Paget's disease of bone
Sign Up to like & getrecommendations! Published in 2020 at "Bone Reports"
DOI: 10.1016/j.bonr.2020.100717
Abstract: Paget's disease of bone (PDB) is a common chronic bone disorder. In the French-Canadian population, the p.Pro392Leu mutation within the SQSTM1 gene is involved in 46% of familial forms. In New Zealand, the emergence of… read more here.
Keywords: pro392leu mutation; offspring carriers; clinical phenotype; adult offspring ... See more keywords
Altered FOXO1 activation in the programming of cardiovascular alterations by maternal diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2018.09.003
Abstract: Maternal diabetes programs cardiovascular alterations in the adult offspring but the mechanisms involved remain unclarified. Here, we addresed whether maternal diabetes programs cardiac alterations related to extracellular matrix remodeling in the adult offspring, as well… read more here.
Keywords: foxo1 activation; adult offspring; maternal diabetes; cardiovascular alterations ... See more keywords
Trajectories of pre- and postnatal co-use of cannabis and tobacco predict co-use and drug use disorders in adult offspring.
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicology and teratology"
DOI: 10.1016/j.ntt.2018.09.002
Abstract: Co-use of cannabis and tobacco is increasingly common among women and is associated with tobacco and cannabis dependence and poorer cessation outcomes. However, no study has examined maternal patterns of co-use over time, or the… read more here.
Keywords: cannabis; tobacco; use; adult offspring ... See more keywords
Enhanced antioxidant capacity prevents epitranscriptomic and cardiac alterations in adult offspring gestationally-exposed to ENM
Sign Up to like & getrecommendations! Published in 2021 at "Nanotoxicology"
DOI: 10.1080/17435390.2021.1921299
Abstract: Abstract Maternal engineered nanomaterial (ENM) exposure during gestation has been associated with negative long-term effects on cardiovascular health in progeny. Here, we evaluate an epitranscriptomic mechanism that contributes to these chronic ramifications and whether overexpression… read more here.
Keywords: enm; antioxidant capacity; mphgpx; exposure ... See more keywords
Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring (P11-003-19).
Sign Up to like & getrecommendations! Published in 2019 at "Current developments in nutrition"
DOI: 10.1093/cdn/nzz048.p11-003-19
Abstract: Objectives We tested the hypothesis that postpartum constitutes a metabolic stress to the nicotinamide adenine dinucleotide (NAD) system and that supplementation of mothers during postpartum with nicotinamide riboside (NR) might improve health outcomes to mothers… read more here.
Keywords: supplemented mothers; nicotinamide riboside; adult offspring; weight loss ... See more keywords
In-utero exposure to antibiotics and risk of colorectal cancer in a prospective cohort of 18 000 adult offspring.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of epidemiology"
DOI: 10.1093/ije/dyad004
Abstract: BACKGROUND Incidence rates of colorectal cancer (CRC) are increasing among younger adults and in mid-life, implicating exposures in early life as risk factors. We examined the association between in-utero exposure to antibiotics and risk of… read more here.
Keywords: acting sulfonamides; adult offspring; utero exposure; cancer ... See more keywords
Short Communication: Maternal undernutrition during peri-conceptional period affects whole genome ovine muscle methylation in adult offspring.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of animal science"
DOI: 10.1093/jas/skac180
Abstract: Experimental and epidemiological studies suggest that maternal nutritional status during early pregnancy, including the period around the time of conception, may induce long-lasting epigenetic changes in the offspring. However, this remains largely unexplored in livestock.… read more here.
Keywords: undernutrition peri; period; conceptional period; muscle ... See more keywords