Lead Optimization to Advance Protease-Activated Receptor-1 Antagonists in Early Discovery.
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DOI: 10.1021/acs.jmedchem.1c02048
Abstract: Vorapaxar is an approved drug for the reduction of thrombotic cardiovascular events in patients with a history of myocardial infarction or with peripheral arterial disease. Subsequent to the discovery of Vorapaxar, medicinal chemistry efforts were… read more here.
Keywords: optimization advance; lead optimization; chemistry; advance protease ... See more keywords