Sonidegib in the Treatment of Locally Advanced Basal Cell Carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Actas dermo-sifiliograficas"
DOI: 10.1016/j.ad.2020.11.002
Abstract: Sonidegib is an antagonist of the transmembrane protein Smoothened in the Hedgehog signaling pathway. It is indicated for the treatment of locally advanced basal cell carcinoma (BCC) that is not amenable to curative surgery or… read more here.
Keywords: advanced basal; cell carcinoma; treatment; basal cell ... See more keywords
Efficacy of sonic hedgehog inhibitors rechallenge, after initial complete response in recurrent advanced basal cell carcinoma: a retrospective study from the CARADERM database.
Sign Up to like & getrecommendations! Published in 2021 at "ESMO open"
DOI: 10.1016/j.esmoop.2021.100284
Abstract: BACKGROUND Smoothened (SMO) inhibitors, blocking the sonic hedgehog pathway, have been approved for advanced basal cell carcinoma (aBCC). Safety analyses reveal a high rate of adverse events (AEs) and, most of the time, vismodegib is… read more here.
Keywords: response; advanced basal; study; efficacy ... See more keywords
Unique Tumor Heterogeneity Within a Single Locally Advanced Basal Cell Carcinoma Resulting in a Partial Response Despite Continuous Vismodegib Treatment.
Sign Up to like & getrecommendations! Published in 2019 at "Dermatologic Surgery"
DOI: 10.1097/dss.0000000000001607
Abstract: Tumor heterogeneity can influence the response of some cancers to treatment. At times, even targeted medications directed toward key signaling pathways may not be effective, posing a challenge in individual patient management. Herein, we report… read more here.
Keywords: advanced basal; tumor heterogeneity; locally advanced; cell carcinoma ... See more keywords
Management of advanced basal cell carcinoma: Real‐life data with sonidegib
Sign Up to like & getrecommendations! Published in 2021 at "Dermatologic Therapy"
DOI: 10.1111/dth.14948
Abstract: Dear Editor Hedgehog inhibitors (HHIs) were recently introduced to the market for the treatment of locally advanced basal cell carcinoma (laBCC) and metastatic BCC demonstrating a high response rate in pivotal studies. Much experience has… read more here.
Keywords: response; advanced basal; cell carcinoma; treatment ... See more keywords
Sonidegib in the Treatment of Locally Advanced Basal Cell Carcinoma: A Retrospective Study
Sign Up to like & getrecommendations! Published in 2022 at "Acta Dermato-Venereologica"
DOI: 10.2340/actadv.v102.1995
Abstract: Sonidegib, a hedgehog pathway inhibitor, is indicated for treatment of locally advanced basal cell carcinoma, based on the results of the BOLT study. However, to date, no real-world study of sonidegib has been reported. An… read more here.
Keywords: locally advanced; advanced basal; cell carcinoma; treatment locally ... See more keywords
Effectiveness, Safety and Utilization of Vismodegib for Locally Advanced Basal Cell Carcinoma Under Real-world Conditions: Non-interventional Cohort Study JONAS
Sign Up to like & getrecommendations! Published in 2022 at "Acta Dermato-Venereologica"
DOI: 10.2340/actadv.v102.293
Abstract: Most patients with advanced basal cell carcinomas (BCCs) may not benefit sufficiently from standard treatment comprising surgery and radiation. Vismodegib, an oral selective hedgehog pathway inhibitor, is approved for treatment of patients with locally advanced… read more here.
Keywords: locally advanced; advanced basal; safety; basal cell ... See more keywords