Is there a role for combined anti–PD‐1/CTLA‐4 checkpoint blockade in the management of advanced biliary tract cancers?
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DOI: 10.1002/cncr.34660
Abstract: Sahai et al. recently reported on a randomized phase 2 trial (BilT‐ 01) investigating chemoimmunotherapy (including the anti–PD‐1 antibody nivolumab) versus combined anti–PD‐1/CTLA‐4 checkpoint blockade (using nivolumab and ipilimumab) in patients with advanced biliary tract… read more here.
Keywords: combination; advanced biliary; tract cancers; treatment ... See more keywords
Predictive factors of the treatment outcome in patients with advanced biliary tract cancer receiving gemcitabine plus cisplatin as first-line chemotherapy
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DOI: 10.1007/s00535-018-1518-3
Abstract: BackgroundFew studies have clearly identified the prognostic factors in patients with advanced biliary tract cancer (BTC) receiving gemcitabine plus cisplatin (GC) which is acknowledged as standard chemotherapy regimen.ObjectivesThe aim of this study was to identify… read more here.
Keywords: biliary tract; chemotherapy; tract cancer; advanced biliary ... See more keywords
Clinical outcomes of gemcitabine, cisplatin plus S-1 in patients with advanced biliary tract cancer
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DOI: 10.1093/annonc/mdz338.010
Abstract: Abstract Background Gemcitabine plus cisplatin has been the standard palliative chemotherapy for patients with advanced biliary tract cancer (aBTC). Recently, the survival benefit of combination chemotherapy with gemcitabine, cisplatin, and S-1 (GCS) was reported, and… read more here.
Keywords: biliary tract; tract cancer; gemcitabine cisplatin; advanced biliary ... See more keywords
Hepatopancreatoduodenectomy for advanced biliary malignancies
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DOI: 10.1097/cm9.0000000000002067
Abstract: Abstract Background: Hepatopancreatoduodenectomy (HPD) has been considered the only curative treatment for metastatic cholangiocarcinoma and some locally advanced gallbladder cancers (GBCs). However, HPD has not yet been included in treatment guidelines as a standard surgical… read more here.
Keywords: hpd; advanced gbc; hepatopancreatoduodenectomy advanced; patients advanced ... See more keywords
Multicentre, phase II study of gemcitabine and S‐1 in patients with advanced biliary tract cancer: TG1308 study
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DOI: 10.1111/liv.14538
Abstract: Gemcitabine plus cisplatin (GC) remains the standard, frontline therapy for advanced biliary tract cancer (ABTC). The JCOG1113 study suggested that gemcitabine plus S‐1 (GS) had noninferior median overall survival and comparable incidence of significant neutropenia… read more here.
Keywords: biliary tract; tract cancer; gemcitabine; study ... See more keywords
Impaired Chromatin Remodeling Predicts Better Survival to Modified Gemcitabine and S-1 plus Nivolumab in Advanced Biliary Tract Cancer: A Phase II T1219 Study
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DOI: 10.1158/1078-0432.ccr-22-1152
Abstract: Abstract Purpose: Modified gemcitabine and S-1 (GS) is an active regimen for patients with advanced biliary tract cancer (ABTC) in our previous study. Herein, we report the results of a single-arm phase II of nivolumab… read more here.
Keywords: cancer; survival; modified gemcitabine; advanced biliary ... See more keywords
Efficacy of fluoropyrimidine-based chemotherapy in patients with advanced biliary cancer after failure of gemcitabine plus cisplatin: Retrospective analysis of 321 patients.
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DOI: 10.1200/jco.2017.35.4_suppl.425
Abstract: 425Background: In advanced biliary tract cancer (BTC), the role of 2nd line chemotherapy after failure of 1st line gemcitabine plus cisplatin (GEMCIS) has not been established. Fluoropyrimidine(FP)-based regimens are widely used as 2nd line treatment… read more here.
Keywords: chemotherapy; 2nd line; gemcitabine plus; line ... See more keywords
Skeletal muscle depletion to predict survival of patients with advanced biliary tract cancer undergoing palliative chemotherapy.
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DOI: 10.1200/jco.2017.35.4_suppl.460
Abstract: 460Background: Reports regarding sarcopenia as a prognostic factor in advanced biliary tract cancer (BTC) are rare. Furthermore, no study has investigated the dynamics of body weight with body muscle mass as a prognostic factor in… read more here.
Keywords: chemotherapy; biliary tract; tract cancer; muscle ... See more keywords
A multicenter phase II trial of rucaparib in combination with nivolumab as maintenance therapy for patients with advanced biliary tract cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.tps4153
Abstract: TPS4153 Background: Patients (pts) with advanced biliary tract cancers (BTC) have a poor prognosis with a median overall survival (OS) less than 12 months. Using whole exome NGS, 26 (49%) pts in a 53 pt… read more here.
Keywords: biliary tract; therapy; combination; advanced biliary ... See more keywords
Effect of Adjuvant Gemcitabine Combined with Low-dose 5-Fluorouracil and Cisplatin Chemotherapy for Advanced Biliary Carcinoma.
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DOI: 10.21873/anticanres.12096
Abstract: BACKGROUND/AIM The aim of this retrospective study was to clarify the effectiveness of chemotherapy with gemcitabine combined with low-dose 5-fluorouracil and cisplatin (GFP) for advanced biliary carcinoma after hepatectomy. PATIENTS AND METHODS Sixty-two patients had… read more here.
Keywords: chemotherapy; biliary carcinoma; advanced biliary; adjuvant gfp ... See more keywords
The Efficacy of Different Chemotherapy Regimens for Advanced Biliary Tract Cancer: A Systematic Review and Network Meta-Analysis
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DOI: 10.3389/fonc.2019.00441
Abstract: Background: Although gemcitabine plus cisplatin (GP) is considered as standard chemotherapy for patients with advanced biliary tract cancer (BTC), the optimal regimen remains unknown. Methods: Using Network meta-analysis (NMA), a systematic review was conducted to… read more here.
Keywords: chemotherapy; biliary tract; tract cancer; advanced biliary ... See more keywords