Is it Time to Consider Eliminating Surgery from the Treatment of Locally Advanced Bladder Cancer?
Sign Up to like & getrecommendations! Published in 2020 at "European urology"
DOI: 10.1016/j.eururo.2020.08.022
Abstract: The similar clinical behavior, overlapping therapeutic patterns, and several clinical trials addressing the neoadjuvant and first-line therapy settings for bladder cancer support the call for a more uniform definition of "locally advanced" disease. We highlight… read more here.
Keywords: bladder cancer; advanced bladder; locally advanced; surgery ... See more keywords
Care planning priorities of older patients with advanced bladder cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of geriatric oncology"
DOI: 10.1016/j.jgo.2022.01.010
Abstract: OBJECTIVES Advanced bladder cancer (ABC) disproportionately affects older adults, and little is known about older patients' priorities for care planning in advanced cancer. Patient-centered communication remains crucial to shared decision-making between patients, families, and providers.… read more here.
Keywords: cancer; older patients; communication; care ... See more keywords
Inhibition of Pyruvate Kinase M2 Markedly Reduces Chemoresistance of Advanced Bladder Cancer to Cisplatin
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DOI: 10.1038/srep45983
Abstract: Chemoresistance to cisplatin is a principal cause of treatment failure and mortality of advanced bladder cancer (BC). The underlying mechanisms remain unclear, which hinders the development of preventive strategies. Recent data indicate that pyruvate kinase… read more here.
Keywords: pyruvate kinase; chemoresistance; cisplatin; inhibition ... See more keywords
MP24-20 PALLIATIVE CARE IN PATIENTS WITH ADVANCED BLADDER CANCER IN THE US
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Urology"
DOI: 10.1097/ju.0000000000000857.020
Abstract: INTRODUCTION AND OBJECTIVE:Palliative care improves quality of life for patients with advanced bladder cancer. Nevertheless, it is neither well defined nor incorporated in urological guidelines. Th... read more here.
Keywords: palliative care; bladder cancer; patients advanced; advanced bladder ... See more keywords
Cost-effectiveness of pembrolizumab in second-line advanced bladder cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.6_suppl.472
Abstract: 472Background: Recently, immune-modulating drugs have been introduced to the second line setting of advanced bladder cancer. Pembrolizumab increases overall survival and is associated with less toxicity compared to chemotherapy in this setting based on the… read more here.
Keywords: bladder cancer; cost; advanced bladder; second line ... See more keywords
Immune-Checkpoint Inhibitors in Advanced Bladder Cancer: Seize the Day
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DOI: 10.3390/biomedicines10020411
Abstract: Background: In advanced bladder cancer (BCa), platinum-based chemotherapy represents the first-choice treatment. In the last ten years, immune checkpoint inhibitors (ICIs) have changed the therapeutic landscape of many solid tumors. Our review aims to summarize… read more here.
Keywords: bladder cancer; checkpoint inhibitors; advanced bladder; immune checkpoint ... See more keywords
New Directions and Challenges in Targeted Therapies of Advanced Bladder Cancer: The Role of FGFR Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14061416
Abstract: Simple Summary The aim of this study was to present and analyze the up-to-date literature describing the epidemiology, genetics, and histopathology of bladder cancer, as well as the latest methods of bladder cancer treatment. The… read more here.
Keywords: fgfr inhibitors; treatment; advanced bladder; bladder cancer ... See more keywords
Molecularly Targeted Therapy towards Genetic Alterations in Advanced Bladder Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14071795
Abstract: Simple Summary In recent years, there have been several advances in the care of advanced bladder cancer, highlighted by the addition of immune checkpoint inhibitors to the care of advanced disease. Despite these advances, there… read more here.
Keywords: bladder; genetic alterations; genetic aberrations; advanced bladder ... See more keywords
Proteasomal Processing Immune Escape Mechanisms in Platinum-Treated Advanced Bladder Cancer
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DOI: 10.3390/genes13030422
Abstract: In recent years, the number and type of treatment options in advanced bladder cancer (BC) have been rapidly evolving. To select an effective therapy and spare unnecessary side effects, predictive biomarkers are urgently needed. As… read more here.
Keywords: bladder cancer; platinum treated; immune escape; advanced bladder ... See more keywords
Advanced Bladder Cancer: Changing the Treatment Landscape
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12101745
Abstract: Bladder cancer is the 10th most common cancer type in the world. There were more than 573,000 new cases of bladder cancer in 2020. It is the 13th most common cause of cancer death with… read more here.
Keywords: cancer changing; treatment; advanced bladder; bladder cancer ... See more keywords