Variation in hospital utilization of palliative interventions for patients with advanced gastrointestinal cancer near end of life
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.27177
Abstract: Patients with advanced gastrointestinal (GI) cancer often undergo noncurative interventions with palliative intent to relieve high symptom burden near end of life. Hospital‐level variation in intervention utilization remains unclear. read more here.
Keywords: gastrointestinal cancer; advanced gastrointestinal; end life; patients advanced ... See more keywords
Attitudes of Patients With Gastrointestinal Cancers Toward Research Biopsies
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Colorectal Cancer"
DOI: 10.1016/j.clcc.2016.09.008
Abstract: Background: Research biopsies are an increasingly important component of clinical trials, but there are concerns that biopsies may deter patients from participating in research. Patients and Methods: Patients participating in a single‐center study investigating the… read more here.
Keywords: advanced gastrointestinal; research; consented biopsy; gastrointestinal cancers ... See more keywords
Is multivisceral resection in locally advanced gastrointestinal stromal tumours an acceptable strategy?
Sign Up to like & getrecommendations! Published in 2017 at "ANZ Journal of Surgery"
DOI: 10.1111/ans.13518
Abstract: Gastrointestinal stromal tumours (GISTs) represent the most common mesenchymal tumour of the gastrointestinal tract. Although the efficacy of targeted therapy cannot be over‐emphasized, surgery remains the only curative primary treatment for patients with localized disease.… read more here.
Keywords: advanced gastrointestinal; gastrointestinal stromal; stromal tumours; locally advanced ... See more keywords
Target‐controlled propofol infusion with or without bispectral index monitoring of sedation during advanced gastrointestinal endoscopy
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.14943
Abstract: Target‐controlled infusion (TCI) uses averaged pharmacokinetic datasets derived from population samples to automatically control the infusion rate. Bispectral index (BIS) technology non‐invasively measures levels of consciousness during surgical procedures. We compared the efficacy and safety… read more here.
Keywords: advanced gastrointestinal; monitoring sedation; infusion; bispectral index ... See more keywords
Phase II Study of Ponatinib in Advanced Gastrointestinal Stromal Tumors: Efficacy, Safety, and Impact of Liquid Biopsy and Other Biomarkers
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-21-2037
Abstract: Abstract Purpose: The purpose of this study is to evaluate ponatinib for advanced gastrointestinal stromal tumors (GIST). Patients and Methods: This single-arm phase II trial enrolled patients with metastatic and/or unresectable GIST with failure of… read more here.
Keywords: kit; advanced gastrointestinal; ponatinib advanced; ex11 positive ... See more keywords
Phase Ib trial of pembrolizumab and XL888 in patients with advanced gastrointestinal malignancies.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.4_suppl.tps526
Abstract: TPS526Background: Heat shock protein 90 (HSP90) has a central role in modulating tumor microenvironment, inflammatory signaling pathways (NF-κB, HIF-1α and Jak-STAT), tumor antigen presentation and... read more here.
Keywords: advanced gastrointestinal; xl888 patients; pembrolizumab xl888; patients advanced ... See more keywords
Treatment of advanced gastrointestinal cancer with genetically modified autologous mesenchymal stem cells: Final results of the phase 1/2 TREAT-ME-1 trial.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e14648
Abstract: e14648 Background: TREAT-ME-1, a Phase 1/2 open-label, first-in-human, first-in-class trial, evaluated the safety, tolerability and efficacy of treatment with genetically modified autologous mesenchymal stromal cells (MSC),MSC_ apceth_101, in combination with ganciclovir in patients with advanced… read more here.
Keywords: genetically modified; treatment; msc apceth; advanced gastrointestinal ... See more keywords
Outcomes of advanced gastrointestinal (GI) cancer patients in relationship to opioid use: An individual patient data pooled analysis from eight clinical trials.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.4_suppl.687
Abstract: 687Background: The current study aims at assessing the patterns of opioid use, and evaluating the impact of opioid use on survival outcomes among patients with advanced GI cancers who were included... read more here.
Keywords: advanced gastrointestinal; use; opioid use; gastrointestinal cancer ... See more keywords
Ripretinib Versus Sunitinib in Patients With Advanced Gastrointestinal Stromal Tumor After Treatment With Imatinib (INTRIGUE): A Randomized, Open-Label, Phase III Trial
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.22.00294
Abstract: PURPOSE Sunitinib, a multitargeted tyrosine kinase inhibitor (TKI), is approved for advanced gastrointestinal stromal tumor (GIST) after imatinib failure. Ripretinib is a switch-control TKI approved for advanced GIST after prior treatment with three or more… read more here.
Keywords: ripretinib versus; sunitinib; advanced gastrointestinal; versus sunitinib ... See more keywords
Treatment of advanced gastrointestinal cancer with genetically modified autologous mesenchymal stem cells - TREAT-ME-1 - a phase I, first in human, first in class trial
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.20964
Abstract: Purpose This phase I, first in human, first in class clinical study aimed at evaluating the safety, tolerability and efficacy of treatment with genetically modified mesenchymal stromal cells (MSC) in combination with ganciclovir (GCV). MSC_apceth_101… read more here.
Keywords: advanced gastrointestinal; phase first; treatment; apceth 101 ... See more keywords
Ripretinib in advanced gastrointestinal stromal tumors: an overview of current evidence and drug approval.
Sign Up to like & getrecommendations! Published in 2022 at "Future oncology"
DOI: 10.2217/fon-2022-0226
Abstract: Over the past 20 years, the management of gastrointestinal stromal tumors has acted as an important model in the advancement of molecularly targeted therapies for solid tumors. The success of imatinib has established it as a… read more here.
Keywords: stromal tumors; advanced gastrointestinal; evidence; ripretinib advanced ... See more keywords