Adoption of single agent anticancer therapy for advanced hepatocellular carcinoma and impact of facility type, insurance status, and income on survival: Analysis of the national cancer database 2004–2014
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DOI: 10.1002/cam4.3985
Abstract: This study analyzes the pattern of use of single agent anticancer therapy (SAACT) in the treatment and survival of advanced hepatocellular carcinoma (aHCC) before and after sorafenib was FDA approved in 2007. read more here.
Keywords: hepatocellular carcinoma; single agent; agent anticancer; advanced hepatocellular ... See more keywords
Treatment outcomes of advanced hepatocellular carcinoma in real‐life practice: Chemotherapy versus multikinase inhibitors
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DOI: 10.1002/cam4.5224
Abstract: Multikinase inhibitors (MKIs) represent the main treatment options for advanced hepatocellular carcinoma (aHCC). However, accessibility in developing countries is limited. A chemotherapy, Fluorouracil and Oxaliplatin (FOLFOX), offers a less expensive treatment. Therefore, this study sought… read more here.
Keywords: hepatocellular carcinoma; multikinase inhibitors; real life; advanced hepatocellular ... See more keywords
Postprogression treatment of lenvatinib plus PD-1 inhibitor in advanced hepatocellular carcinoma refractory to HAIC.
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DOI: 10.1002/cncr.34764
Abstract: PURPOSE This study compares the efficacy and safety of lenvatinib and programmed cell death protein (PD)-1 versus lenvatinib alone for advanced hepatocellular carcinoma (Ad-HCC) refractory to hepatic arterial infusion chemotherapy (HAIC). METHODS From April 2016… read more here.
Keywords: hepatocellular carcinoma; advanced hepatocellular; postprogression; group ... See more keywords
Effect of early adverse events resulting in sorafenib dose adjustments on survival outcomes of advanced hepatocellular carcinoma patients
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DOI: 10.1007/s10147-020-01698-7
Abstract: Background Sorafenib is a current first-line treatment option for advanced hepatocellular carcinoma (HCC). This study aimed to evaluate the impact of early adverse events (AEs) requiring sorafenib dose adjustment on survival outcomes of patients with… read more here.
Keywords: hepatocellular carcinoma; survival outcomes; sorafenib; sorafenib dose ... See more keywords
Impact of Hepatectomy for Advanced Hepatocellular Carcinoma with Major Portal Vein Tumor Thrombus
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DOI: 10.1007/s11605-021-05181-0
Abstract: Optimal treatment strategies for advanced hepatocellular carcinoma (HCC) with macroscopic portal vein tumor thrombus (PVTT) remain controversial. Therefore, this study aimed to assess the impact and predictive factors of hepatectomy for HCC with macroscopic PVTT.… read more here.
Keywords: hepatocellular carcinoma; pvtt; impact; portal vein ... See more keywords
Treatment Patterns and Economic Burden by Lines of Therapy Among Patients with Advanced Hepatocellular Carcinoma Treated with Systemic Cancer Therapy
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DOI: 10.1007/s12029-019-00230-z
Abstract: Purpose This study examined clinical and economic outcomes among patients with advanced hepatocellular carcinoma (HCC) treated with systemic agents by line of therapy. Methods Adults with ≥ 2 medical claims for primary diagnosed HCC (from January… read more here.
Keywords: hepatocellular carcinoma; patients advanced; among patients; treatment ... See more keywords
Successful multimodality treatment for advanced hepatocellular carcinoma with tumor thrombosis of the main portal trunk: a case study
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DOI: 10.1007/s12328-021-01481-9
Abstract: The overall survival of patients with advanced hepatocellular carcinoma with tumor thrombosis of the main trunk or bilobar branches of the portal vein is extremely poor. Moreover, there is no standard treatment established for the… read more here.
Keywords: hepatocellular carcinoma; tumor thrombosis; treatment; advanced hepatocellular ... See more keywords
Introducing immunotherapy for advanced hepatocellular carcinoma patients: Too early or too fast?
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DOI: 10.1016/j.critrevonc.2020.103167
Abstract: Advanced hepatocellular carcinoma (HCC) is the most frequent liver cancer. Immunotherapy has been explored in this disease in order to improve survival outcomes. Nowadays, scientific research is focusing especially on immune checkpoint inhibitors, in particular… read more here.
Keywords: hepatocellular carcinoma; immunotherapy; immunotherapy advanced; advanced hepatocellular ... See more keywords
Immunological inflammatory biomarkers as prognostic predictors for advanced hepatocellular carcinoma.
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DOI: 10.1016/j.esmoop.2020.100020
Abstract: BACKGROUND The immunological inflammatory biomarkers for advanced hepatocellular carcinoma are unclear. We aimed to investigate the association of immunity and inflammatory status with treatment outcomes in patients with advanced hepatocellular carcinoma who received molecular-targeted agents… read more here.
Keywords: hepatocellular carcinoma; ratio; neutrophil lymphocyte; advanced hepatocellular ... See more keywords
Total skeletal, psoas and rectus abdominis muscle mass as prognostic factors for patients with advanced hepatocellular carcinoma.
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DOI: 10.1016/j.jfma.2020.07.005
Abstract: PURPOSE We investigated whether low skeletal muscle mass (LSMM) defined according to different muscle groups on computed tomography (CT) scans are predictive factors of survival for advanced hepatocellular carcinoma (HCC). METHODS In this retrospective study,… read more here.
Keywords: hepatocellular carcinoma; rectus abdominis; total skeletal; muscle ... See more keywords
Sorafenib with or without concurrent transarterial chemoembolization in patients with advanced hepatocellular carcinoma: The phase III STAH trial.
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DOI: 10.1016/j.jhep.2018.11.029
Abstract: BACKGROUND & AIMS Sorafenib is first-line standard of care for patients with advanced hepatocellular carcinoma (HCC), yet it confers limited survival benefit. Therefore, we aimed to compare clinical outcomes of sorafenib combined with concurrent conventional… read more here.
Keywords: hepatocellular carcinoma; sorafenib alone; sorafenib; advanced hepatocellular ... See more keywords