Adoption of single agent anticancer therapy for advanced hepatocellular carcinoma and impact of facility type, insurance status, and income on survival: Analysis of the national cancer database 2004–2014
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DOI: 10.1002/cam4.3985
Abstract: This study analyzes the pattern of use of single agent anticancer therapy (SAACT) in the treatment and survival of advanced hepatocellular carcinoma (aHCC) before and after sorafenib was FDA approved in 2007. read more here.
Keywords: hepatocellular carcinoma; single agent; agent anticancer; advanced hepatocellular ... See more keywords
Treatment outcomes of advanced hepatocellular carcinoma in real‐life practice: Chemotherapy versus multikinase inhibitors
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DOI: 10.1002/cam4.5224
Abstract: Multikinase inhibitors (MKIs) represent the main treatment options for advanced hepatocellular carcinoma (aHCC). However, accessibility in developing countries is limited. A chemotherapy, Fluorouracil and Oxaliplatin (FOLFOX), offers a less expensive treatment. Therefore, this study sought… read more here.
Keywords: hepatocellular carcinoma; multikinase inhibitors; real life; advanced hepatocellular ... See more keywords
Durvalumab Monotherapy in Complex Advanced Hepatocellular Carcinoma: A Real‐World Study of Patients Ineligible for Combination Immunotherapy
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DOI: 10.1002/cam4.70642
Abstract: Combination immunotherapy is the standard of care for advanced hepatocellular carcinoma (HCC). However, some patients are unsuitable for such treatment. This study investigated the safety and effectiveness of durvalumab monotherapy in a real‐world cohort with… read more here.
Keywords: durvalumab monotherapy; real world; advanced hepatocellular; hepatocellular carcinoma ... See more keywords
Organ‐Specific Responses to Nivolumab Plus Ipilimumab in Advanced Hepatocellular Carcinoma: A Multicenter, Retrospective Study
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DOI: 10.1002/cam4.70997
Abstract: Immune checkpoint inhibitor (ICI) monotherapy elicits limited intrahepatic responses in patients with advanced hepatocellular carcinoma (HCC). Here, we investigate the organ‐specific objective response rate (OSORR) of nivolumab plus ipilimumab (Nivo/Ipi) combination treatment, considering prior ICI… read more here.
Keywords: organ specific; plus ipilimumab; advanced hepatocellular; hepatocellular carcinoma ... See more keywords
Anti‐Angiogenic Agents for Advanced Hepatocellular Carcinoma Induce Liver Atrophy
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DOI: 10.1002/cam4.71066
Abstract: Systemic therapy for advanced hepatocellular carcinoma (HCC) includes multi‐kinase inhibitors with anti‐vascular endothelial growth factor (VEGF) activity and anti‐VEGF monoclonal antibodies in combination with immune checkpoint inhibitors. This study aimed to investigate and compare the… read more here.
Keywords: anti angiogenic; agents advanced; angiogenic agents; advanced hepatocellular ... See more keywords
Postprogression treatment of lenvatinib plus PD-1 inhibitor in advanced hepatocellular carcinoma refractory to HAIC.
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DOI: 10.1002/cncr.34764
Abstract: PURPOSE This study compares the efficacy and safety of lenvatinib and programmed cell death protein (PD)-1 versus lenvatinib alone for advanced hepatocellular carcinoma (Ad-HCC) refractory to hepatic arterial infusion chemotherapy (HAIC). METHODS From April 2016… read more here.
Keywords: hepatocellular carcinoma; advanced hepatocellular; postprogression; group ... See more keywords
The use of peripheral CD3+γδ+Vδ2+ T lymphocyte cells in combination with the ALBI score to predict immunotherapy response in patients with advanced hepatocellular carcinoma: a retrospective study
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DOI: 10.1007/s00432-024-05896-y
Abstract: Currently, there is a lack of effective indicators for predicting the efficacy of immunotherapy in patients with advanced hepatocellular carcinoma (HCC). This study aimed to investigate the expression and prognostic value of peripheral T lymphocyte… read more here.
Keywords: advanced hcc; advanced hepatocellular; hepatocellular carcinoma; patients advanced ... See more keywords
Effect of early adverse events resulting in sorafenib dose adjustments on survival outcomes of advanced hepatocellular carcinoma patients
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DOI: 10.1007/s10147-020-01698-7
Abstract: Background Sorafenib is a current first-line treatment option for advanced hepatocellular carcinoma (HCC). This study aimed to evaluate the impact of early adverse events (AEs) requiring sorafenib dose adjustment on survival outcomes of patients with… read more here.
Keywords: hepatocellular carcinoma; survival outcomes; sorafenib; sorafenib dose ... See more keywords
Impact of Hepatectomy for Advanced Hepatocellular Carcinoma with Major Portal Vein Tumor Thrombus
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DOI: 10.1007/s11605-021-05181-0
Abstract: Optimal treatment strategies for advanced hepatocellular carcinoma (HCC) with macroscopic portal vein tumor thrombus (PVTT) remain controversial. Therefore, this study aimed to assess the impact and predictive factors of hepatectomy for HCC with macroscopic PVTT.… read more here.
Keywords: hepatocellular carcinoma; pvtt; impact; portal vein ... See more keywords
Treatment Patterns and Economic Burden by Lines of Therapy Among Patients with Advanced Hepatocellular Carcinoma Treated with Systemic Cancer Therapy
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DOI: 10.1007/s12029-019-00230-z
Abstract: Purpose This study examined clinical and economic outcomes among patients with advanced hepatocellular carcinoma (HCC) treated with systemic agents by line of therapy. Methods Adults with ≥ 2 medical claims for primary diagnosed HCC (from January… read more here.
Keywords: hepatocellular carcinoma; patients advanced; among patients; treatment ... See more keywords
Comprehensive genomic profiling for advanced hepatocellular carcinoma in clinical practice
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DOI: 10.1007/s12072-024-10741-y
Abstract: Although several therapeutic agents show efficacy in advanced hepatocellular carcinoma (HCC), biomarkers such as comprehensive genomic profiling (CGP) for the selection of second-line treatments after immunotherapy have not been established. We evaluated the value of… read more here.
Keywords: genomic profiling; cgp; advanced hepatocellular; hepatocellular carcinoma ... See more keywords