Scar‐Degrading Endothelial Cells as a Treatment for Advanced Liver Fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202203315
Abstract: Deposition of extracellular matrix (ECM) in the liver is an important feature of liver cirrhosis. Recovery from liver cirrhosis is physiologically challenging, partially due to the ECM in scar tissue showing resistance to cell‐mediated degradation… read more here.
Keywords: liver fibrosis; endothelial cells; degrading endothelial; advanced liver ... See more keywords
Direct acting antivirals for patients without advanced liver disease: All for treatment and treatment for all?
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.29873
Abstract: The recent advent of all-oral direct-acting antivirals (DAAs) has revolutionized the treatment of hepatitis C virus (HCV). Although access to HCV treatment has been improving in the United States (attributed to increased competition, negotiated lower… read more here.
Keywords: treatment; hcv; advanced liver; liver disease ... See more keywords
Prevalence, Evolution, and Risk Factors for Advanced Liver Fibrosis in Adults Undergoing Intestinal Transplantation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Parenteral and Enteral Nutrition"
DOI: 10.1002/jpen.1148
Abstract: INTRODUCTION Intestinal failure-associated liver disease (IFALD) occurs commonly in intestinal transplant (ITx) candidates receiving parenteral nutrition (PN). The aim of this study is to establish the prevalence and risk factors for advanced liver fibrosis in… read more here.
Keywords: fibrosis; liver fibrosis; factors advanced; risk factors ... See more keywords
Advanced Liver Fibrosis Is Associated with Necroinflammatory Grade but Not Hepatic Steatosis in Chronic Hepatitis B Patients
Sign Up to like & getrecommendations! Published in 2021 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-020-06761-x
Abstract: Patients with chronic hepatitis B (CHB) are at an increased risk of disease progression. The influence of hepatic steatosis (HS) to liver fibrosis was controversial. We aim to investigate the association between HS and liver… read more here.
Keywords: hepatic steatosis; fibrosis; liver fibrosis; advanced liver ... See more keywords
A Combination Model of Radiomics Features and Clinical Biomarkers as a Nomogram to Differentiate Nonadvanced From Advanced Liver Fibrosis: A Retrospective Study.
Sign Up to like & getrecommendations! Published in 2021 at "Academic radiology"
DOI: 10.1016/j.acra.2020.08.029
Abstract: RATIONALE AND OBJECTIVES To develop and validate a combination model of radiomics features and clinical biomarkers to differentiate nonadvanced from advanced liver fibrosis. MATERIALS AND METHODS One hundred and eight consecutive patients with pathologically diagnosed… read more here.
Keywords: advanced liver; model; combination model; liver fibrosis ... See more keywords
Real-world Comorbidity Burden, Health Care Utilization, and Costs of Nonalcoholic Steatohepatitis Patients With Advanced Liver Diseases
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Gastroenterology"
DOI: 10.1097/mcg.0000000000001409
Abstract: Supplemental Digital Content is available in the text. Goals: This study evaluates the real-world comorbidity burden, health care resource utilization (HRU), and costs among nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH) patients with advanced liver diseases… read more here.
Keywords: comorbidity burden; liver diseases; advanced liver; nafld nash ... See more keywords
Role of IL-28B genetic variants in HCV-related liver disease severity in patients with different viral genotypes
Sign Up to like & getrecommendations! Published in 2018 at "Medicine"
DOI: 10.1097/md.0000000000009782
Abstract: Abstract Reports of the role of host interleukin 28B (IL-28B) genetic variants in liver disease severity in patients with chronic hepatitis C (CHC) have obtained conflicting results. The impact of IL-28B in Asian patients with… read more here.
Keywords: fibrosis; liver fibrosis; genetic variants; advanced liver ... See more keywords
Treatment of chronic hepatitis C with direct‐acting antivirals in patients with β‐thalassaemia major and advanced liver disease
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Haematology"
DOI: 10.1111/bjh.14640
Abstract: Interferon‐based regimens for chronic hepatitis C (CHC) were often deferred in patients with β‐thalasaemia major (β‐TM) due to poor efficacy and tolerance. Current guidelines recommend direct‐acting antivirals (DAAs) for these patients. The aim of this… read more here.
Keywords: rbv; hepatitis; disease; advanced liver ... See more keywords
Multi-omics profiling of primary hepatic stellate cells from advanced liver fibrosis patients reveals distinctive molecular signatures.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of gastroenterology and hepatology"
DOI: 10.1111/jgh.16221
Abstract: BACKGROUND AND AIM Hepatic fibrosis is a common pathogenic outcome of almost all chronic liver diseases and a growing public health problem globally. However, the key genes or proteins driving liver fibrosis and cirrhosis are… read more here.
Keywords: stellate cells; liver fibrosis; primary hepatic; hepatic stellate ... See more keywords
Safety analysis of glecaprevir/pibrentasvir in patients with markers of advanced liver disease in clinical and real‐world cohorts
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Viral Hepatitis"
DOI: 10.1111/jvh.13738
Abstract: Chronic hepatitis C virus (HCV) infection has the greatest health impact in patients with advanced liver disease. The direct‐acting antiviral (DAA) regimen glecaprevir/pibrentasvir (G/P) is approved for treatment of HCV‐infected patients without cirrhosis and with… read more here.
Keywords: markers advanced; safety; advanced liver; liver disease ... See more keywords
Automatic Segmentation of Magnetic Resonance Images of Severe Patients with Advanced Liver Cancer and the Molecular Mechanism of Emodin-Induced Apoptosis of HepG2 Cells under the Deep Learning
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Healthcare Engineering"
DOI: 10.1155/2022/3951112
Abstract: To improve the accuracy of clinical diagnosis of severe patients with advanced liver cancer and enhance the effect of chemotherapy treatment, the U-Net model was optimized by introducing the batch normalization (BN) layer and the… read more here.
Keywords: liver cancer; severe patients; patients advanced; segmentation ... See more keywords