Meta‐analysis of the effect of extending the interval after long‐course chemoradiotherapy before surgery in locally advanced rectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Surgery"
DOI: 10.1002/bjs.11220
Abstract: The current standard of care in locally advanced rectal cancer (LARC) is neoadjuvant long‐course chemoradiotherapy (nCRT) followed by total mesorectal excision (TME). Surgery is conventionally performed approximately 6–8 weeks after nCRT. This study aimed to determine… read more here.
Keywords: surgery; rectal cancer; long course; course chemoradiotherapy ... See more keywords
Neoadjuvant chemoradiotherapy with capecitabine and irinotecan guided by UGT1A1 status in patients with locally advanced rectal cancer: 5‐year update of the CinClare trial
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DOI: 10.1002/cac2.70058
Abstract: The optimal regimen and chemotherapy intensity are still under investigation for neoadjuvant treatment of locally advanced rectal cancer (LARC). The CinClare trial has demonstrated improved pathologic complete response (pCR) with the addition of irinotecan to… read more here.
Keywords: cancer; neoadjuvant chemoradiotherapy; cinclare trial; rectal cancer ... See more keywords
Neoadjuvant concurrent chemoradiotherapy using infusional gemcitabine in locally advanced rectal cancer: A phase II trial.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer medicine"
DOI: 10.1002/cam4.4590
Abstract: INTRODUCTION Gemcitabine is a well-known radiosensitizer. Herein, we tested the efficacy and toxicity of preoperative concurrent infusional gemcitabine and radiotherapy in locally advanced rectal cancer. PATIENTS AND METHODS This was a phase II, single-arm trial.… read more here.
Keywords: advanced rectal; gemcitabine; infusional gemcitabine; locally advanced ... See more keywords
Radiomic score for lung nodules as a prognostic biomarker in locally advanced rectal cancer patients: A bi‐institutional study
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DOI: 10.1002/cam4.7240
Abstract: Undetermined lung nodules are common in locally advanced rectal cancer (LARC) and lack precise risk stratification. This study aimed to develop a radiomic‐based score (Rad‐score) to distinguish metastasis and predict overall survival (OS) in patients… read more here.
Keywords: cancer; lung nodules; score; advanced rectal ... See more keywords
Prognostic significance of neoadjuvant rectal score in locally advanced rectal cancer after neoadjuvant chemoradiotherapy and construction of a prediction model
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DOI: 10.1002/jso.24907
Abstract: To evaluate the prognostic significance of neoadjuvant rectal (NAR) score after neoadjuvant chemoradiotherapy (nCRT) for locally advanced rectal cancer (LARC), and to develop a nomogram predicting disease‐free survival (DFS). read more here.
Keywords: significance neoadjuvant; neoadjuvant chemoradiotherapy; advanced rectal; locally advanced ... See more keywords
MRI‐detected extramural vascular invasion (mrEMVI) as the best predictive factor to identify candidates to total neoadjuvant therapy in locally advanced rectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.26818
Abstract: Chemotherapy in locally advanced rectal cancer (LARC) is shifting from an adjuvant setting to a total neoadjuvant therapy (TNT) strategy, that relies on distant metastases (DM) risk prediction. This study aims to assess the accuracy… read more here.
Keywords: locally advanced; neoadjuvant therapy; total neoadjuvant; rectal cancer ... See more keywords
Can sarcopenia predict complete response after total neoadjuvant therapy in advanced rectal cancer? A multicentre observational cohort study.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of surgical oncology"
DOI: 10.1002/jso.27251
Abstract: BACKGROUND The association between sarcopenia and response to neoadjuvant treatment remains unclear. This study investigates sarcopenia as a predictor of overall complete response (oCR) after Total Neoadjuvant Therapy (TNT) for advanced rectal cancer. METHOD A… read more here.
Keywords: complete response; rectal cancer; response; study ... See more keywords
The Impact of Intraoperative Radiotherapy on Margin Positive Locally Advanced Rectal Cancer: A Propensity‐Matched Analysis of The National Cancer Database
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DOI: 10.1002/jso.70102
Abstract: Intraoperative radiotherapy (IORT) is utilized as an adjunctive treatment in advanced rectal cancer, particularly in cases with threatened surgical margins. Although IORT has shown benefits in enhancing local tumor control, its impact on overall survival… read more here.
Keywords: cancer; cancer database; rectal cancer; advanced rectal ... See more keywords
Performance of diffusion-weighted magnetic resonance imaging at 3.0T for early assessment of tumor response in locally advanced rectal cancer treated with preoperative chemoradiation therapy
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DOI: 10.1007/s00261-018-1457-8
Abstract: PurposeThe purpose of the article is to determine whether changes in apparent diffusion coefficient (ADC) values of locally advanced rectal cancer (LARC) obtained 2 weeks after the beginning of chemoradiation therapy (CRT) allow to predict treatment… read more here.
Keywords: diffusion; response; rectal cancer; advanced rectal ... See more keywords
Diagnostic performance of magnetic resonance to assess treatment response after neoadjuvant therapy in patients with locally advanced rectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Abdominal Radiology"
DOI: 10.1007/s00261-019-01894-8
Abstract: PurposeOur study aimed to evaluate the diagnostic performance of rectal magnetic resonance imaging (MRI) for local restaging in patients with non-metastatic locally advanced rectal cancer (LARC) after neoadjuvant chemoradiotherapy (CRT) using surgical histopathology of total… read more here.
Keywords: diagnostic performance; response; rectal cancer; magnetic resonance ... See more keywords
Is Early Initiation of Adjuvant Chemotherapy Beneficial for Locally Advanced Rectal Cancer Following Neoadjuvant Chemoradiotherapy and Radical Surgery?
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DOI: 10.1007/s00268-020-05573-4
Abstract: Aim This study aimed to evaluate whether earlier initiation ( read more here.
Keywords: surgery; initiation; adjuvant chemotherapy; act ... See more keywords