Meta‐analysis of the effect of extending the interval after long‐course chemoradiotherapy before surgery in locally advanced rectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Surgery"
DOI: 10.1002/bjs.11220
Abstract: The current standard of care in locally advanced rectal cancer (LARC) is neoadjuvant long‐course chemoradiotherapy (nCRT) followed by total mesorectal excision (TME). Surgery is conventionally performed approximately 6–8 weeks after nCRT. This study aimed to determine… read more here.
Keywords: surgery; rectal cancer; long course; course chemoradiotherapy ... See more keywords
Neoadjuvant concurrent chemoradiotherapy using infusional gemcitabine in locally advanced rectal cancer: A phase II trial.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer medicine"
DOI: 10.1002/cam4.4590
Abstract: INTRODUCTION Gemcitabine is a well-known radiosensitizer. Herein, we tested the efficacy and toxicity of preoperative concurrent infusional gemcitabine and radiotherapy in locally advanced rectal cancer. PATIENTS AND METHODS This was a phase II, single-arm trial.… read more here.
Keywords: advanced rectal; gemcitabine; infusional gemcitabine; locally advanced ... See more keywords
Prognostic significance of neoadjuvant rectal score in locally advanced rectal cancer after neoadjuvant chemoradiotherapy and construction of a prediction model
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.24907
Abstract: To evaluate the prognostic significance of neoadjuvant rectal (NAR) score after neoadjuvant chemoradiotherapy (nCRT) for locally advanced rectal cancer (LARC), and to develop a nomogram predicting disease‐free survival (DFS). read more here.
Keywords: significance neoadjuvant; neoadjuvant chemoradiotherapy; advanced rectal; locally advanced ... See more keywords
MRI‐detected extramural vascular invasion (mrEMVI) as the best predictive factor to identify candidates to total neoadjuvant therapy in locally advanced rectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.26818
Abstract: Chemotherapy in locally advanced rectal cancer (LARC) is shifting from an adjuvant setting to a total neoadjuvant therapy (TNT) strategy, that relies on distant metastases (DM) risk prediction. This study aims to assess the accuracy… read more here.
Keywords: locally advanced; neoadjuvant therapy; total neoadjuvant; rectal cancer ... See more keywords
Can sarcopenia predict complete response after total neoadjuvant therapy in advanced rectal cancer? A multicentre observational cohort study.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of surgical oncology"
DOI: 10.1002/jso.27251
Abstract: BACKGROUND The association between sarcopenia and response to neoadjuvant treatment remains unclear. This study investigates sarcopenia as a predictor of overall complete response (oCR) after Total Neoadjuvant Therapy (TNT) for advanced rectal cancer. METHOD A… read more here.
Keywords: complete response; rectal cancer; response; study ... See more keywords
Performance of diffusion-weighted magnetic resonance imaging at 3.0T for early assessment of tumor response in locally advanced rectal cancer treated with preoperative chemoradiation therapy
Sign Up to like & getrecommendations! Published in 2018 at "Abdominal Radiology"
DOI: 10.1007/s00261-018-1457-8
Abstract: PurposeThe purpose of the article is to determine whether changes in apparent diffusion coefficient (ADC) values of locally advanced rectal cancer (LARC) obtained 2 weeks after the beginning of chemoradiation therapy (CRT) allow to predict treatment… read more here.
Keywords: diffusion; response; rectal cancer; advanced rectal ... See more keywords
Diagnostic performance of magnetic resonance to assess treatment response after neoadjuvant therapy in patients with locally advanced rectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Abdominal Radiology"
DOI: 10.1007/s00261-019-01894-8
Abstract: PurposeOur study aimed to evaluate the diagnostic performance of rectal magnetic resonance imaging (MRI) for local restaging in patients with non-metastatic locally advanced rectal cancer (LARC) after neoadjuvant chemoradiotherapy (CRT) using surgical histopathology of total… read more here.
Keywords: diagnostic performance; response; rectal cancer; magnetic resonance ... See more keywords
Is Early Initiation of Adjuvant Chemotherapy Beneficial for Locally Advanced Rectal Cancer Following Neoadjuvant Chemoradiotherapy and Radical Surgery?
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DOI: 10.1007/s00268-020-05573-4
Abstract: Aim This study aimed to evaluate whether earlier initiation ( read more here.
Keywords: surgery; initiation; adjuvant chemotherapy; act ... See more keywords
Response prediction of neoadjuvant chemoradiation therapy in locally advanced rectal cancer using CT-based fractal dimension analysis
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DOI: 10.1007/s00330-021-08303-z
Abstract: There are individual variations in neo-adjuvant chemoradiation therapy (nCRT) in patients with locally advanced rectal cancer (LARC). No reliable modality currently exists that can predict the efficacy of nCRT. The purpose of this study is… read more here.
Keywords: rectal cancer; analysis; advanced rectal; fractal dimension ... See more keywords
Predictive factors of complete pathological response in patients with locally advanced rectal cancer
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DOI: 10.1007/s00384-020-03633-8
Abstract: Patients with locally advanced rectal cancer who achieve pathologic complete response (pCR) following neoadjuvant therapy have better long-term outcomes and could be spared from the perioperative and long-term morbidity of rectal resection. The aim of… read more here.
Keywords: rectal cancer; response; advanced rectal; patients locally ... See more keywords
Mutation in BRAF and SMAD4 associated with resistance to neoadjuvant chemoradiation therapy in locally advanced rectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Virchows Archiv"
DOI: 10.1007/s00428-019-02576-y
Abstract: Our study was done in order to identify novel molecular markers to predict which locally advanced rectal cancers (LARCs) might be resistant to neoadjuvant chemoradiotherapy (nCRT). Seventy-four patients with LARCs treated with nCRT were collected.… read more here.
Keywords: trg tumors; advanced rectal; trg; locally advanced ... See more keywords