Advances in pharmacotherapy for advanced thyroid cancer of follicular origin (PTC, FTC). New approved drugs and future therapies
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2022.2030704
Abstract: ABSTRACT Introduction The most common altered signaling found in aggressive iodine-refractory thyroid cancers derived from follicular cells (RAI-TC) are RTK, MAPK, PI3K, WNT, BRAF, RAS, RET, and TP53. Tyrosine Kinase Inhibitors (TKI) are multi-kinase inhibitors… read more here.
Keywords: advanced thyroid; pharmacotherapy advanced; thyroid; origin ... See more keywords
A systematic review of endotracheal stenting in patients with locally advanced thyroid cancer
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DOI: 10.1111/coa.13923
Abstract: Locally aggressive thyroid cancer can result in airway obstruction secondary to tracheal compression or vocal cord palsy. A tracheal stent provides an alternative to surgical resection, tracheostomy or conservative management in patients with compressive symptoms.… read more here.
Keywords: locally advanced; advanced thyroid; thyroid; systematic review ... See more keywords
Molecular Profile of Advanced Thyroid Carcinomas by Next-Generation Sequencing: Characterizing Tumors Beyond Diagnosis for Targeted Therapy
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DOI: 10.1158/1535-7163.mct-17-0871
Abstract: Next-generation sequencing (NGS) for molecular diagnostics allows simultaneous testing of activating oncogenes and tumor suppressor mutations in multiple signal pathways. Extended mutational profiling of advanced thyroid cancers may enhance considerations for targeted therapies. We analyzed… read more here.
Keywords: thyroid carcinomas; thyroid carcinoma; poorly differentiated; advanced thyroid ... See more keywords
Lenvatinib induces early tumor shrinkage in patients with advanced thyroid carcinoma.
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DOI: 10.1507/endocrj.ej17-0104
Abstract: Although advanced thyroid carcinoma patients who cannot be cured by conventional therapy have lacked effective treatment, multitargeted tyrosine kinase inhibitors have recently become available. Phase 3 trials of lenvatinib showed a median time to objective… read more here.
Keywords: early tumor; advanced thyroid; thyroid carcinoma; tumor shrinkage ... See more keywords
The Possible Role of Cancer Stem Cells in the Resistance to Kinase Inhibitors of Advanced Thyroid Cancer
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DOI: 10.3390/cancers12082249
Abstract: Target therapy with various kinase inhibitors (KIs) has been extended to patients with advanced thyroid cancer, but only a subset of these compounds has displayed efficacy in clinical use. However, after an initial response to… read more here.
Keywords: kinase inhibitors; advanced thyroid; thyroid cancer; resistance ... See more keywords
Pilot Study on the Impact of Polymorphisms Linked to Multi-Kinase Inhibitor Metabolism on Lenvatinib Side Effects in Patients with Advanced Thyroid Cancer
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DOI: 10.3390/ijms24065496
Abstract: Multi-kinase inhibitors (MKIs) represent the best therapeutic option in advanced thyroid cancer patients. The therapeutic efficacy and toxicity of MKIs are very heterogeneous and are difficult to predict before starting treatment. Moreover, due to the… read more here.
Keywords: multi kinase; thyroid cancer; advanced thyroid; side effects ... See more keywords
Nutrition in Advanced Thyroid Cancer Patients
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DOI: 10.3390/nu14061298
Abstract: In the last decade, multikinase inhibitors (MKIs) have changed the paradigm of treatment of advanced and progressive thyroid cancer. Compared with the traditional treatment with chemotherapy and radiotherapy, these new drugs have shown a good… read more here.
Keywords: advanced thyroid; nutrition advanced; cancer patients; thyroid cancer ... See more keywords