Corrigendum to: Recent advances in the discovery of heparanase inhibitors as anti-cancer agents [Eur. J. Mech. 121 (2016) 209-220].
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.09.092
Abstract: The authors regret that the Graphical Abstract on p. vii, and Fig. 2, on p. 212 contain incorrect structures and apologise for any inconvenience caused. The correct structures are shown below in the Graphical Abstract… read more here.
Keywords: discovery heparanase; anti cancer; heparanase inhibitors; advances discovery ... See more keywords
Advances in the discovery of exosome inhibitors in cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2020.1754814
Abstract: Abstract Exosomes are small membrane vesicles released by most eukaryotic cells. They are considered to play an essential role in cell-to-cell communication, and It is also found that they serve as functional mediators in many… read more here.
Keywords: discovery exosome; advances discovery; chemistry; exosome inhibitors ... See more keywords
Advances in the discovery of microRNA-based anticancer therapeutics: latest tools and developments
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2020.1690449
Abstract: ABSTRACT Introduction: MicroRNAs (miRNAs) are small endogenous non-coding RNAs that repress the expression of their target genes by reducing mRNA stability and/or inhibiting translation. miRNAs are known to be aberrantly regulated in cancers. Modulators of… read more here.
Keywords: cancer; advances discovery; target effects; anticancer therapeutics ... See more keywords
Advances in the discovery of new chemotypes through ultra-large library docking
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DOI: 10.1080/17460441.2023.2171984
Abstract: ABSTRACT Introduction The size and complexity of virtual screening libraries in drug discovery have skyrocketed in recent years, reaching up to multiple billions of accessible compounds. However, virtual screening of such ultra-large libraries poses several… read more here.
Keywords: chemotypes ultra; discovery new; virtual screening; ultra large ... See more keywords
Advances in the discovery of drugs that treat pulmonary arterial hypertension
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DOI: 10.1080/17460441.2023.2192919
Abstract: ABSTRACT Introduction Distal pulmonary arterial remodeling and elevated pulmonary vascular resistance are characteristic of pulmonary arterial hypertension (PAH). Current approved vasodilator-specific PAH therapy that includes phosphodiesterase-5 inhibitors, soluble guanylate cyclase stimulators, endothelin receptor antagonists, and… read more here.
Keywords: arterial hypertension; pulmonary arterial; advances discovery; signaling pathways ... See more keywords
Advances in the Discovery of Novel Inhaled PI3Kδ Inhibitors for the Treatment of Asthma.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220819115011
Abstract: Bronchial asthma is the most common chronic respiratory illness, the incidence of which continues to increase annually. Currently, effective treatments for CS-resistant asthma and severe asthma are still lacking, and new therapeutic regimens are urgently… read more here.
Keywords: pi3k; discovery novel; inhaled pi3k; asthma ... See more keywords
Recent Advances in the Discovery of Novel Antiprotozoal Agents
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24213886
Abstract: Parasitic diseases have serious health, social, and economic impacts, especially in the tropical regions of the world. Diseases caused by protozoan parasites are responsible for considerable mortality and morbidity, affecting more than 500 million people… read more here.
Keywords: antiprotozoal agents; advances discovery; discovery novel; recent advances ... See more keywords
Recent Advances in Discovery of Lead Structures from Microbial Natural Products: Genomics- and Metabolomics-Guided Acceleration
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DOI: 10.3390/molecules26092542
Abstract: Natural products (NPs) are evolutionarily optimized as drug-like molecules and remain the most consistently successful source of drugs and drug leads. They offer major opportunities for finding novel lead structures that are active against a… read more here.
Keywords: natural products; advances discovery; discovery lead; lead structures ... See more keywords
An update on the recent advances and discovery of novel tubulin colchicine binding inhibitors.
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DOI: 10.4155/fmc-2022-0212
Abstract: Microtubules, formed by α- and β-tubulin heterodimer, are considered as a major target to prevent the proliferation of tumor cells. Microtubule-targeted agents have become increasingly effective anticancer drugs. However, due to the relatively sophisticated chemical… read more here.
Keywords: discovery novel; colchicine binding; advances discovery; update recent ... See more keywords
Recent advances in the discovery of small-molecule inhibitors of HIV-1 integrase
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DOI: 10.4155/fsoa-2018-0060
Abstract: AIDS caused by the infection of HIV is a prevalent problem today. Rapid development of drug resistance to existing drug classes has called for the discovery of new targets. Within the three major enzymes (i.e.,… read more here.
Keywords: discovery small; hiv; advances discovery; small molecule ... See more keywords