Advances in targeted degradation of endogenous proteins
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03112-6
Abstract: Protein silencing is often employed as a means to aid investigations in protein function and is increasingly desired as a therapeutic approach. Several types of protein silencing methodologies have been developed, including targeting the encoding… read more here.
Keywords: protein; degradation endogenous; degradation; advances targeted ... See more keywords
Advances in targeted nanotherapeutics: From bioconjugation to biomimicry
Sign Up to like & getrecommendations! Published in 2018 at "Nano Research"
DOI: 10.1007/s12274-018-2083-z
Abstract: Since the emergence of cancer nanomedicine, researchers have had intense interest in developing nanoparticles (NPs) that can specifically target diseased sites while avoiding healthy tissue to mitigate the off-target effects seen with conventional treatments like… read more here.
Keywords: bioconjugation; bioconjugation biomimicry; advances targeted; nanotherapeutics bioconjugation ... See more keywords
Recent advances in targeted nanomedicine as promising antitumor therapeutics.
Sign Up to like & getrecommendations! Published in 2020 at "Drug discovery today"
DOI: 10.1016/j.drudis.2020.09.031
Abstract: A tumor serves as a major avenue in drug development owing to its complexity. Conventional therapies against tumors possess limitations such as suboptimal therapeutic efficacy and extreme side effects. These display poor pharmacokinetics and lack… read more here.
Keywords: promising antitumor; antitumor therapeutics; advances targeted; nanomedicine promising ... See more keywords
Advances in targeted therapy for esophageal cancer
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DOI: 10.1038/s41392-020-00323-3
Abstract: Esophageal cancer (EC) is one of the most lethal cancers in the world, and its morbidity and mortality rates rank among the top ten in China. Currently, surgical resection, radiotherapy and chemotherapy are the primary… read more here.
Keywords: esophageal cancer; advances targeted; treatment; targeted therapy ... See more keywords
Advances in targeted therapy mainly based on signal pathways for nasopharyngeal carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-00340-2
Abstract: Nasopharyngeal carcinoma (NPC) is a malignant epithelial carcinoma of the head and neck region which mainly distributes in southern China and Southeast Asia and has a crucial association with the Epstein–Barr virus. Based on epidemiological… read more here.
Keywords: advances targeted; therapy mainly; targeted therapy; signal pathways ... See more keywords
Recent advances in targeted nanotherapeutic approaches for breast cancer management.
Sign Up to like & getrecommendations! Published in 2021 at "Nanomedicine"
DOI: 10.2217/nnm-2021-0281
Abstract: Breast cancer is the most commonly occurring tumor disease worldwide. Breast cancer is currently managed by conventional chemotherapy, which is inadequate in curbing this heterogeneous disease and results in off-site toxic effects, suggesting effective treatment approaches… read more here.
Keywords: cancer; breast cancer; recent advances; advances targeted ... See more keywords
Advances of Targeted Therapy for Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.719896
Abstract: Hepatocellular carcinoma (HCC) is one of the common and fatal malignancies, which is a significant global health problem. The clinical applicability of traditional surgery and other locoregional therapies is limited, and these therapeutic strategies are… read more here.
Keywords: hepatocellular carcinoma; targeted therapy; advances targeted; advanced hcc ... See more keywords
Recent Advances in Targeted Therapies for Advanced Gastrointestinal Malignancies
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DOI: 10.3390/cancers12051168
Abstract: The treatment of advanced gastrointestinal (GI) cancers has become increasingly molecularly driven. Molecular profiling for HER2 and PD-L1 status is standard for metastatic gastroesophageal (GEJ) cancers to predict benefits from trastuzumab (HER2-targeted therapy) and pembrolizumab… read more here.
Keywords: advanced gastrointestinal; targeted therapies; advances targeted; recent advances ... See more keywords
Advances in Targeted Immunotherapy for Hepatobiliary Cancers
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232213961
Abstract: Cancer of the hepatobiliary system can be divided into primary liver cancer and biliary tract cancer (BTC), which includes hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), and gallbladder cancer (GBC). These aggressive cancers often present at an… read more here.
Keywords: liver; hcc btc; hcc; advances targeted ... See more keywords
Molecular Basis and Advances in Targeted Immunotherapy for Cancer
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24097802
Abstract: Researchers have long attempted to stimulate the immune system of cancer patients as a therapeutic strategy [...]. read more here.
Keywords: targeted immunotherapy; immunotherapy cancer; advances targeted; basis advances ... See more keywords