Recent advances in targeting DNA repair pathways for the treatment of ovarian cancer and their clinical relevance
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Clinical Oncology"
DOI: 10.1007/s10147-017-1137-7
Abstract: Poly (ADP-ribose) polymerase (PARP) inhibitors have attracted much attention as one of the major molecular-targeted therapeutics for inhibiting DNA damage response. The PARP inhibitor, olaparib, has been clinically applied for treating certain recurrent ovarian cancer… read more here.
Keywords: targeting dna; cancer clinical; advances targeting; ovarian cancer ... See more keywords
Therapeutic advances in the targeting of ROR1 in hematological cancers
Sign Up to like & getrecommendations! Published in 2024 at "Cell Death Discovery"
DOI: 10.1038/s41420-024-02239-1
Abstract: Receptor tyrosine kinases (RTKs) are key cell surface receptors involved in cell communication and signal transduction, with great importance in cell growth, differentiation, survival, and metabolism. Dysregulation of RTKs, such as EGFR, VEGFR, HER2 or… read more here.
Keywords: targeting ror1; therapeutic advances; advances targeting; ror1 hematological ... See more keywords
Advances in targeting and heterologous expression of genes involved in the synthesis of fungal secondary metabolites
Sign Up to like & getrecommendations! Published in 2019 at "RSC Advances"
DOI: 10.1039/c9ra06908a
Abstract: Gene targeting involves integration of foreign DNA into the fungal genome by several strategies including Agrobacterium tumefaciens-mediated transformation (ATMT). read more here.
Keywords: genes involved; involved synthesis; expression genes; advances targeting ... See more keywords
Recent advances in targeting malaria with nanotechnology-based drug carriers
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2021.1948568
Abstract: Abstract Malaria, as one of the most common human infectious diseases, remains the greatest global health concern, since approximately 3.5 billion people around the world, especially those in subtropical areas, are at the risk of… read more here.
Keywords: drug; advances targeting; recent advances; targeting malaria ... See more keywords
Advances in targeting estrogen synthesis and receptors in patients with endometriosis
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2022.2152325
Abstract: ABSTRACT Introduction Endometriosis is an estrogen-dependent disease on the background of progesterone resistance. Increased estrogen production, low estrogen metabolization, and altered estrogen receptors (ERs) expression contribute to the hyperestrogenic milieu within endometriotic lesions. Since estrogens… read more here.
Keywords: estrogen; disease; synthesis receptors; advances targeting ... See more keywords
Advances in targeting cancer-associated fibroblasts through single-cell spatial transcriptomic sequencing
Sign Up to like & getrecommendations! Published in 2024 at "Biomarker Research"
DOI: 10.1186/s40364-024-00622-9
Abstract: Cancer-associated fibroblasts (CAFs) are the major components of the tumor microenvironment and are related to tumor proliferation, metastasis, relapse, and drug resistance. With the development of sequencing technologies, single-cell RNA sequencing has become a popular… read more here.
Keywords: single cell; advances targeting; cell; associated fibroblasts ... See more keywords
The advances in targeting CD47/SIRPα “do not eat me” axis and their ongoing challenges as an anticancer therapy
Sign Up to like & getrecommendations! Published in 2024 at "Oncotarget"
DOI: 10.18632/oncotarget.28607
Abstract: The growing understanding of the tumor immune microenvironment and its significance in shaping treatment outcomes has directed the latest advances in cancer therapy to boost antitumor immune responses. read more here.
Keywords: eat axis; therapy; advances targeting; sirp eat ... See more keywords
Recent advances in targeting protein kinases and pseudokinases in cancer biology
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.942500
Abstract: Kinases still remain the most favorable members of the druggable genome, and there are an increasing number of kinase inhibitors approved by the FDA to treat a variety of cancers. Here, we summarize recent developments… read more here.
Keywords: kinases pseudokinases; advances targeting; biology; recent advances ... See more keywords
Advances in targeting protein S-palmitoylation in tumor immunity and therapy
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2025.1547636
Abstract: S-palmitoylation is a reversible and dynamic post-translational modification of proteins. A palmitoyl group is covalently attached to a cysteine residue of the protein by a thioester link. It regulates the transcription and expression of downstream… read more here.
Keywords: targeting protein; advances targeting; palmitoylation; tumor ... See more keywords
Advances in Targeting HPV Infection as Potential Alternative Prophylactic Means
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22042201
Abstract: Infection by oncogenic human papillomavirus (HPV) is the primary cause of cervical cancer and other anogenital cancers. The majority of cervical cancer cases occur in low- and middle- income countries (LMIC). Concurrent infection with Human… read more here.
Keywords: infection potential; infection; cervical cancer; advances targeting ... See more keywords