Evaluating the Advantages of Using 3D-Enriched Fragments for Targeting BET Bromodomains.
Sign Up to like & getrecommendations! Published in 2019 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.9b00414
Abstract: Fragment-based ligand discovery has been successful in targeting diverse proteins. Despite drug-like molecules having more 3D character, traditional fragment libraries are largely composed of flat, aromatic fragments. The use of 3D-enriched fragments for enhancing library… read more here.
Keywords: bet bromodomains; bet; advantages using; enriched fragments ... See more keywords
The Advantages of Using a Bleed of Air from Behind the Compressor and Supplying It Behind the Turbine in an Aircraft Engine
Sign Up to like & getrecommendations! Published in 2020 at "Journal of KONBiN"
DOI: 10.2478/jok-2020-0067
Abstract: Abstract The research paper discusses the advantages of using compressor downstream air partial bleed and supplying it downstream of the turbine, which was applied in a prototype of a “bypass” turbojet engine. The impact of… read more here.
Keywords: turbine; compressor; bleed; engine ... See more keywords
Advantages of Using Extremophilic Bacteria for the Biosynthesis of Metallic Nanoparticles and Its Potential for Rare Earth Element Recovery
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.855077
Abstract: The exceptional potential for application that metallic nanoparticles (MeNPs) have shown, has steadily increased their demand in many different scientific and technological areas, including the biomedical and pharmaceutical industry, bioremediation, chemical synthesis, among others. To… read more here.
Keywords: biosynthesis; rare earth; using extremophilic; advantages using ... See more keywords
Advantages of Using Paclitaxel in Combination with Oncolytic Adenovirus Utilizing RNA Destabilization Mechanism
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12051210
Abstract: Oncolytic virotherapy is a novel approach to cancer therapy. Ad-fosARE is a conditionally replicative adenovirus engineered by inserting AU-rich elements (ARE) in the 3’-untranslated region of the E1A gene. In this study, we examined the… read more here.
Keywords: combination; using paclitaxel; adenovirus; advantages using ... See more keywords
Advantages of Using Triboscopic Imaging: Case Studies on Carbon Coatings in Non-Lubricated Friction Conditions
Sign Up to like & getrecommendations! Published in 2022 at "Materials"
DOI: 10.3390/ma15124317
Abstract: Triboscopy focuses on the analysis of the temporal evolution of a tribological system, combining local and time-resolved information, most commonly the evolution of friction. In this work, this technique is applied on measurements, which were… read more here.
Keywords: carbon coatings; using triboscopic; friction; triboscopic imaging ... See more keywords