Attenuation of Maladaptive Responses in Aortic Adventitial Fibroblasts through Stimuli‐Triggered siRNA Release from Lipid–Polymer Nanocomplexes
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Biosystems"
DOI: 10.1002/adbi.201700099
Abstract: Lipid–siRNA assemblies are modified with photoresponsive polymers to enable spatiotemporally controlled silencing of interleukin 1 beta (IL1β) and cadherin 11 (CDH11), two genes that are essential drivers of maladaptive responses in human aortic adventitial fibroblasts.… read more here.
Keywords: adventitial fibroblasts; lipid polymer; attenuation maladaptive; aortic adventitial ... See more keywords
Endothelial Cells Inhibit the Angiotensin II Induced Phenotypic Modulation of Rat Vascular Adventitial Fibroblasts
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25941
Abstract: The phenotypic modulation of vascular adventitial fibroblasts plays an important role in vascular remodeling. Evidence have shown that endothelial cells and adventitial fibroblasts interact under certain conditions. In this study, we investigated the influence of… read more here.
Keywords: adventitial fibroblasts; vascular adventitial; endothelial cells; phenotypic modulation ... See more keywords
Hydrogen sulfide diminishes activation of adventitial fibroblasts via the inhibition of mitochondrial fission.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cardiovascular pharmacology"
DOI: 10.1097/fjc.0000000000001250
Abstract: ABSTRACT Activation of adventitial fibroblasts (AFs) upon vascular injury contributes to vascular remodeling. Hydrogen sulfide (H2S), a gaseous signal molecule, modulates various cardiovascular functions. The aim of this study was to explore whether exogenous H2S… read more here.
Keywords: hydrogen sulfide; mitochondrial fission; activation adventitial; fission ... See more keywords
Fibronectin type III domain containing 5 attenuates NLRP3 inflammasome activation and phenotypic transformation of adventitial fibroblasts in spontaneously hypertensive rats
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hypertension"
DOI: 10.1097/hjh.0000000000001654
Abstract: Objective: Phenotypic transformation of adventitial fibroblasts is important in the pathogenesis of hypertension. This study was designed to determine whether fibronectin type III domain containing 5 (FNDC5) alleviates the phenotypic transformation of adventitial fibroblasts in… read more here.
Keywords: phenotypic transformation; inflammasome activation; adventitial fibroblasts; transformation adventitial ... See more keywords
Infiltration of meningeal macrophages into the Virchow–Robin space after ischemic stroke in rats: Correlation with activated PDGFR-β-positive adventitial fibroblasts
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.1033271
Abstract: Macrophages play a crucial role in wound healing and fibrosis progression after brain injury. However, a detailed analysis of their initial infiltration and interaction with fibroblasts is yet to be conducted. This study aimed to… read more here.
Keywords: adventitial fibroblasts; space; pdgfr positive; virchow robin ... See more keywords
Adventitial Fibroblasts in Aortic Aneurysm: Unraveling Pathogenic Contributions to Vascular Disease
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostics"
DOI: 10.3390/diagnostics12040871
Abstract: Aortic aneurysm (AA) is a degenerative vascular disease that involves aortic dilatation, and, if untreated, it can lead to rupture. Despite its significant impact on the healthcare system, its multifactorial nature and elusive pathophysiology contribute… read more here.
Keywords: vascular disease; fibroblasts aortic; aortic aneurysm; aneurysm unraveling ... See more keywords
Urotensin II promotes aldosterone expression in rat aortic adventitial fibroblasts
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2017.8233
Abstract: Urotensin II (UII) contributes to cardiovascular diseases by activating vasoactive peptides. The present study aimed to determine the effect of UII on aldosterone (ALD) and its receptor in cultured adventitial fibroblasts (AFs) and the tunica… read more here.
Keywords: tunica adventitia; adventitial fibroblasts; expression; adventitia rat ... See more keywords
Urotensin II activates the ferroptosis pathway through circ0004372/miR-124/SERTAD4 to promote the activation of vascular adventitial fibroblasts.
Sign Up to like & getrecommendations! Published in 2022 at "General physiology and biophysics"
DOI: 10.4149/gpb_2022027
Abstract: Both vascular adventitial fibroblasts (VAFs) and urotensin II (UII) play important roles in vascular remodeling diseases, but the mechanism of UII in VAFs is still unclear. UII inhibited miR-124 expression through up-regulating circ0004372 expression, thereby… read more here.
Keywords: adventitial fibroblasts; mir 124; expression; circ0004372 mir ... See more keywords
Norepinephrine acting on adventitial fibroblasts stimulates vascular smooth muscle cell proliferation via promoting small extracellular vesicle release
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.70974
Abstract: Excessive sympathetic activity and norepinephrine (NE) release play crucial roles in the pathogeneses of hypertension. Sympathetic fibers innervate adventitia rather than media of arteries. However, the roles of NE in adventitial fibroblasts (AFs) are unknown.… read more here.
Keywords: evs release; adventitial fibroblasts; proliferation; vascular smooth ... See more keywords