Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience.
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DOI: 10.1002/bcp.70276
Abstract: PROBLEM SETTING The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is… read more here.
Keywords: early phase; adverse immunostimulation; ais; drug ... See more keywords