Serum IL-1ra, a novel biomarker predicting olanzapine-induced hypercholesterolemia and hyperleptinemia in schizophrenia
Sign Up to like & getrecommendations! Published in 2018 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2018.01.020
Abstract: ABSTRACT Olanzapine (OLZ) is efficacious whereas leads to adverse metabolic effects thus lead to higher risk of cardiovascular diseases (CVD) on schizophrenia. Cytokines have been found associated with metabolic disorders. Therefore, pretreatment prediction of OLZ‐induced… read more here.
Keywords: schizophrenia; treatment; adverse metabolic; hypercholesterolemia hyperleptinemia ... See more keywords
Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-18165-6
Abstract: Despite the clear association between myocardial injury, heart failure and depressed myocardial energetics, little is known about upstream signals responsible for remodeling myocardial metabolism after pathological stress. Here, we report increased mitochondrial calmodulin kinase II… read more here.
Keywords: causes adverse; mitochondrial camkii; adverse metabolic; camkii ... See more keywords
Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation
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DOI: 10.7554/elife.72452
Abstract: Background: Some individuals living with obesity may be relatively metabolically healthy, whilst others suffer from multiple conditions that may be linked to adverse metabolic effects or other factors. The extent to which the adverse metabolic… read more here.
Keywords: adverse metabolic; disease; higher adiposity; adiposity ... See more keywords