Iridium-Catalyzed Aerobic α,β-Dehydrogenation of γ,δ-Unsaturated Amides and Acids: Activation of Both α- and β-C-H bonds through an Allyl-Iridium Intermediate.
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DOI: 10.1021/jacs.7b11351
Abstract: Direct aerobic α,β-dehydrogenation of γ,δ-unsaturated amides and acids using a simple iridium/copper relay catalysis system is described. We developed a new strategy that overcomes the challenging issue associated with the low α-acidity of amides and… read more here.
Keywords: amides acids; unsaturated amides; iridium; dehydrogenation unsaturated ... See more keywords
Synthesis of conjugated dienes via palladium-catalysed aerobic dehydrogenation of unsaturated acids and amides.
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DOI: 10.1039/d2cc02896d
Abstract: A Pd(II)-catalyzed direct aerobic dehydrogenation of γ,δ-olefinic acids and amides has been demonstrated. The present protocol dehydrogenates the least acidic amides and acids, thus replacing the traditional enolate strategy for dehydrogenation. A broad spectrum of… read more here.
Keywords: acids amides; synthesis conjugated; aerobic dehydrogenation; dienes via ... See more keywords