An Experimental Toolbox for Structure‐Based Hit Discovery for P. aeruginosa FabF, a Promising Target for Antibiotics
Sign Up to like & getrecommendations! Published in 2021 at "Chemmedchem"
DOI: 10.1002/cmdc.202100302
Abstract: FabF (3‐oxoacyl‐[acyl‐carrier‐protein] synthase 2), which catalyses the rate limiting condensation reaction in the fatty acid synthesis II pathway, is an attractive target for new antibiotics. Here, we focus on FabF from P. aeruginosa (PaFabF) as antibiotics against this… read more here.
Keywords: fabf; target; structure based; structure ... See more keywords
Synthesis and antimicrobial evaluation of piperic acid amides and their lower homologues
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DOI: 10.1002/ddr.21630
Abstract: Seven piperic acid amides along with their lower homologs (12) were synthesized using HATU‐DIPEA coupling reagent. All the synthesized derivatives were evaluated for their antibacterial activities against Staphylococcus aureus, Pseudomonas aeruginosa, and vancomycin‐resistant P. aeruginosa.… read more here.
Keywords: acid amides; piperic acid; found active; synthesis antimicrobial ... See more keywords
Effect of natural curcuminoids‐intercalated layered double hydroxide nanohybrid against Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis: A bactericidal, antibiofilm, and mechanistic study
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DOI: 10.1002/mbo3.723
Abstract: The study aimed to determine the antibacterial/antibiofilm effect and mechanism of interaction of curcuminoids‐intercalated Mg/Al layered double hydroxide (curcuminoids‐LDH) against three different bacteria. Antimicrobial effect of curcuminoids‐LDH nanohybrid was investigated against P. aeruginosa, S. aureus,… read more here.
Keywords: curcuminoids intercalated; aureus; effect; curcuminoids ldh ... See more keywords
Impacts of potassium ferrate(VI) on the growth and organic matter accumulation, production, and structural changes in the cyanobacterium Microcystis aeruginosa
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-017-8757-3
Abstract: Cyanobacterial blooms generated by nutrient addition into aquatic systems pose serious risks to ecosystems and human health. Though there are established chemical, physical, and biological means of eradication, more efficient and environmentally friendly measures are… read more here.
Keywords: matter; cyanobacterium microcystis; organic matter; ferrate growth ... See more keywords
Osteopontin exacerbates Pseudomonas aeruginosa-induced bacteremia in mice.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2017.05.004
Abstract: Osteopontin (OPN) is a multifunctional protein involved in various pathophysiological processes. However, the role of OPN in Pseudomonas aeruginosa-related sepsis is not yet clear. Here, we found that OPN expression was elevated in plasma and… read more here.
Keywords: aeruginosa induced; pseudomonas aeruginosa; induced bacteremia; osteopontin ... See more keywords
PAHs would alter cyanobacterial blooms by affecting the microcystin production and physiological characteristics of Microcystis aeruginosa.
Sign Up to like & getrecommendations! Published in 2018 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2018.03.052
Abstract: The wide presence of polycyclic aromatic hydrocarbons (PAHs) in lakes necessitates a better understanding of cyanobacteria metabolites under the contamination of PAHs. The M. aeruginosa strain PCC7806 was selected to investigate the effects of naphthalene… read more here.
Keywords: pahs would; production; would alter; microcystin ... See more keywords
Effects of selenite on Microcystis aeruginosa: Growth, microcystin production and its relationship to toxicity under hypersalinity and copper sulfate stresses.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental pollution"
DOI: 10.1016/j.envpol.2017.01.056
Abstract: Se laden freshwater algae that enter the Salton Sea with river water pose ecorisks to wildlife in the lake by transferring selenium (Se) to higher trophic levels. The aim of this study was to investigate… read more here.
Keywords: hypersalinity; toxicity; microcystis aeruginosa; microcystin production ... See more keywords
Toxic Microcystis aeruginosa alters the resource allocation in Daphnia mitsukuri responding to fish predation cues.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental pollution"
DOI: 10.1016/j.envpol.2021.116918
Abstract: Many prey organisms adaptively respond to predation risk by inducible defenses with underlying tradeoffs in resource allocation. Cyanobacterial blooms expose zooplankton to poor food conditions, affecting the herbivores' fitness. Given the interferences on resources allocation… read more here.
Keywords: resource allocation; daphnia mitsukuri; fish predation; aeruginosa ... See more keywords
Release of large amounts of lipopolysaccharides from Pseudomonas aeruginosa cells reduces their susceptibility to colistin.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2018.02.004
Abstract: Pseudomonas aeruginosa is an important etiological agent of opportunistic infections. Injectable colistin is available as a last-line treatment option for multidrug-resistant P. aeruginosa infections. When cells were inoculated at a high number, colistin-susceptible P. aeruginosa… read more here.
Keywords: pseudomonas aeruginosa; fluid; colistin; large amounts ... See more keywords
Comparison of methods to analyse susceptibility of German MDR/XDR Pseudomonas aeruginosa to ceftazidime/avibactam.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2019.05.001
Abstract: Ceftazidime/avibactam (CZA) is a new β-lactam/β-lactamase inhibitor combination with promising properties as avibactam can inhibit a broad range of β-lactamases (e.g. blaKPC, blaOXA-48). The objectives of this study were: (i) to assess CZA susceptibility rates;… read more here.
Keywords: ceftazidime avibactam; xdr pseudomonas; pseudomonas aeruginosa; cza ... See more keywords
Allelopathic inhibition of juglone (5-hydroxy-1,4-naphthoquinone) on the growth and physiological performance in Microcystis aeruginosa.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of environmental management"
DOI: 10.1016/j.jenvman.2018.11.105
Abstract: The elimination of cyanobacteria blooms has become an urgent concern in aquatic environmental protection. Allelopathic control is considered a potential approach because of its exclusive and ecological safety properties. The present study evaluated the allelopathic… read more here.
Keywords: allelopathic inhibition; juglone; microcystis aeruginosa; cell ... See more keywords