Antimicrobial Activity of Ceftolozane-Tazobactam Tested against Contemporary (2015-2017) P. aeruginosa Isolates from a Global Surveillance Program.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2019.10.009
Abstract: OBJECTIVES Ceftolozane-tazobactam (C-T) is an antibacterial combination of an antipseudomonal cephalosporin and a β-lactamase inhibitor. C-T was approved in >60 countries for complicated urinary tract infections, acute pyelonephritis, and complicated intra-abdominal infections in combination with… read more here.
Keywords: ceftolozane tazobactam; 2015 2017; col; activity ... See more keywords
Molecular detection of six virulence genes in Pseudomonas aeruginosa isolates detected in children with urinary tract infection.
Sign Up to like & getrecommendations! Published in 2017 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2017.03.009
Abstract: Although a vast majority of Urinary tract infections (UTIs) are caused by E. coli, epidemiological reports have indicated an increasing rate of such infections caused by some other opportunistic organisms including Pseudomonas aeruginosa. Antimicrobial susceptibility and… read more here.
Keywords: virulence genes; pseudomonas aeruginosa; virulence; antimicrobial susceptibility ... See more keywords
Comparative Activity of Newer β-Lactam/β-Lactamase Inhibitor Combinations against Pseudomonas aeruginosa Isolates from United States Medical Centers (2020-2021).
Sign Up to like & getrecommendations! Published in 2022 at "International journal of antimicrobial agents"
DOI: 10.1093/ofid/ofac492.708
Abstract: OBJECTIVES To evaluate the in vitro activity of ceftazidime-avibactam, ceftolozane-tazobactam, meropenem-vaborbactam, imipenem-relebactam, and comparator agents against contemporary Pseudomonas aeruginosa isolates from United States (US) hospitals. METHODS 3,184 isolates were consecutively collected from 71 US medical… read more here.
Keywords: ceftolozane tazobactam; infection; aeruginosa isolates; ceftazidime avibactam ... See more keywords
Evaluation of biofilm‐specific antimicrobial resistance genes in Pseudomonas aeruginosa isolates in Farabi Hospital
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DOI: 10.1099/jmm.0.000521
Abstract: Background. Biofilm produced from Pseudomonas aeruginosa is the cause of infection induced by contact lenses, trauma and post‐surgery infection. The aim of this study was to evaluate biofilm formation and the presence of the genes… read more here.
Keywords: farabi hospital; pseudomonas aeruginosa; resistance; biofilm ... See more keywords
Molecular Characterization of Baseline Enterobacterales and Pseudomonas aeruginosa Isolates from a Phase 3 Nosocomial Pneumonia (ASPECT-NP) Clinical Trial
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DOI: 10.1128/aac.02461-20
Abstract: We evaluated β-lactam-resistant baseline Enterobacterales species and Pseudomonas aeruginosa lower respiratory tract isolates collected during the ASPECT-NP phase 3 clinical trial evaluating the safety and efficacy of ceftolozane-tazobactam compared with meropenem for the treatment of… read more here.
Keywords: ceftolozane tazobactam; baseline enterobacterales; trial; aeruginosa isolates ... See more keywords
Adaptation to an Amoeba Host Leads to Pseudomonas aeruginosa Isolates with Attenuated Virulence
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DOI: 10.1128/aem.02322-21
Abstract: Pseudomonas aeruginosa is an opportunistic pathogen that causes both acute infections in plants and animals, including humans, and chronic infections in immunocompromised and cystic fibrosis patients. This bacterium is commonly found in soils and water,… read more here.
Keywords: pseudomonas aeruginosa; stage amoeba; aeruginosa isolates; amoeba adapted ... See more keywords
Carbapenem-Nonsusceptible Pseudomonas aeruginosa Isolates from Intensive Care Units in the United States: a Potential Role for New β-Lactam Combination Agents
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Microbiology"
DOI: 10.1128/jcm.00535-19
Abstract: Pseudomonas aeruginosa, a frequent pathogen in the intensive care unit (ICU), has the propensity to develop antibiotic resistance. In particular, carbapenem-nonsusceptible (NS) P. aeruginosa poses tremendous challenges, and new antibiotics will be needed to treat… read more here.
Keywords: aeruginosa isolates; lactam combination; aeruginosa; combination agents ... See more keywords
MOLECULAR MECHANISMS OF CEFTAZIDIME RESISTANCE IN PSEUDOMONAS AERUGINOSA ISOLATES FROM CANINE AND HUMAN INFECTIONS
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DOI: 10.17221/64/2010-vetmed
Abstract: Sixty-six clinical P. aeruginosa isolates, 17 obtained from canine otitis specimens and 49 received from human patients with bloodstream infections, were collected between February 2007 and January 2008. The minimal inhibitory concentrations (MICs) of the… read more here.
Keywords: mechanisms ceftazidime; bla; resistance; ceftazidime resistance ... See more keywords
Impact of concomitant nontuberculous mycobacteria and Pseudomonas aeruginosa isolates in non-cystic fibrosis bronchiectasis
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DOI: 10.2147/idr.s169789
Abstract: Purpose Pseudomonas aeruginosa is associated with pulmonary function decline and high disease severity in non-cystic fibrosis (CF) bronchiectasis. The prevalence of nontuberculous mycobacteria (NTM) in non-CF bronchiectasis patients has increased recently. This study investigated the… read more here.
Keywords: bronchiectasis; non bronchiectasis; group patients; isolates non ... See more keywords
Identification of floR Variants Associated With a Novel Tn4371-Like Integrative and Conjugative Element in Clinical Pseudomonas aeruginosa Isolates
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DOI: 10.3389/fcimb.2021.685068
Abstract: Florfenicol is widely used to control respiratory diseases and intestinal infections in food animals. However, there are increasing reports about florfenicol resistance of various clinical pathogens. floR is a key resistance gene that mediates resistance… read more here.
Keywords: flor variants; pseudomonas aeruginosa; like integrative; tn4371 like ... See more keywords
Competitive fitness of Pseudomonas aeruginosa isolates in human and murine precision-cut lung slices
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DOI: 10.3389/fcimb.2022.992214
Abstract: Chronic respiratory infections with the gram-negative bacterium Pseudomonas aeruginosa are an important co-morbidity for the quality of life and prognosis of people with cystic fibrosis (CF). Such long-term colonization, sometimes lasting up to several decades,… read more here.
Keywords: pseudomonas aeruginosa; aeruginosa isolates; competitive fitness; lung ... See more keywords