The full transforming capacity of MLL-Af4 is interlinked with lymphoid lineage commitment.
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DOI: 10.1182/blood-2017-04-777185
Abstract: Chromosome rearrangements involving the mixed-lineage leukemia gene (MLL) create MLL-fusion proteins, which could drive both acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). The lineage decision of MLL-fusion leukemia is influenced by the fusion… read more here.
Keywords: mll af4; af4 interlinked; lineage; fusion ... See more keywords