AFF4 regulates cellular adipogenic differentiation via targeting autophagy
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DOI: 10.1371/journal.pgen.1010425
Abstract: Transcriptional elongation is a universal and critical step during gene expression. The super elongation complex (SEC) regulates the rapid transcriptional induction by mobilizing paused RNA polymerase II (Pol II). Dysregulation of SEC is closely associated… read more here.
Keywords: adipogenesis; aff4 regulates; adipogenic differentiation; aff4 ... See more keywords
PI3K/ c-Myc/AFF4 axis promotes pancreatic tumorigenesis through fueling nucleotide metabolism
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DOI: 10.7150/ijbs.77150
Abstract: MLL-AFF4 fusion gene has been discovered in acute leukemia, whether AFF4 alone plays a role in tumor, especially pancreatic tumorigenesis, is still elusive. Increasing evidence suggests that cancer cells altered nucleotide metabolism during tumorigenesis. In… read more here.
Keywords: nucleotide metabolism; pancreatic tumorigenesis; hprt1 impdh2; aff4 ... See more keywords