The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations
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DOI: 10.1038/s41467-020-19221-x
Abstract: The ASCC3 subunit of the activating signal co-integrator complex is a dual-cassette Ski2-like nucleic acid helicase that provides single-stranded DNA for alkylation damage repair by the α-ketoglutarate-dependent dioxygenase AlkBH3. Other ASCC components integrate ASCC3/AlkBH3 into… read more here.
Keywords: cancer mutations; affected somatic; dna repair; ascc2 ascc3 ... See more keywords