Network Topology Can Explain Differences in Pleiotropy Between Cis- and Trans-regulatory Mutations
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msac266
Abstract: Abstract A mutation's degree of pleiotropy (i.e., the number of traits it alters) is predicted to impact the probability of the mutation being detrimental to fitness. For mutations that impact gene expression, mutations acting in… read more here.
Keywords: topology; affecting expression; trans regulatory; regulatory mutations ... See more keywords