In silico approach to probe the binding affinity between OMVs harboring the ZEGFR affibody and the EGF receptor
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-022-05043-9
Abstract: There is a growing interest in designing a nanocarrier containing an EGFR targeting affibody to direct toward cancer cells. Here, cytolysin A was cloned at the N-terminus of ZEGFR:1907 affibody to guarantee its surface presentation… read more here.
Keywords: clya affiegfr; affibody; gala; zegfr ... See more keywords
In Vivo Evaluation and Dosimetry Estimate for a High Affinity Affibody PET Tracer Targeting PD-L1
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-020-01544-2
Abstract: Purpose In vivo imaging of programmed death ligand 1 (PD-L1) during immunotherapy could potentially monitor changing PD-L1 expression and PD-L1 expression heterogeneity within and across tumors. Some protein constructs can be used for same-day positron… read more here.
Keywords: affibody; affinity; lox; pet tracer ... See more keywords
Combination of ribosome display and next generation sequencing as a powerful method for identification of affibody binders against β-lactamase CTX-M15.
Sign Up to like & getrecommendations! Published in 2019 at "New biotechnology"
DOI: 10.1016/j.nbt.2019.01.004
Abstract: CTX-M15 is one of the most widespread, extended spectrum β-lactamases, a major determinant of antibiotic resistance representing urgent public health threats, among enterobacterial strains infecting humans and animals. Here we describe the selection of binders… read more here.
Keywords: ctx m15; next generation; affibody; ribosome display ... See more keywords
Affibody Molecules in Biotechnological and Medical Applications.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in biotechnology"
DOI: 10.1016/j.tibtech.2017.04.007
Abstract: Affibody molecules are small (6.5-kDa) affinity proteins based on a three-helix bundle domain framework. Since their introduction 20 years ago as an alternative to antibodies for biotechnological applications, the first therapeutic affibody molecules have now… read more here.
Keywords: biotechnological medical; affibody; affibody molecules; molecules biotechnological ... See more keywords
Discovery of a Non-competitive TNFR1 Antagonist Affibody with Picomolar Monovalent Potency That Does Not Affect TNFR2 Function.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00385
Abstract: Tumor necrosis factor (TNF) is a key regulator of immune responses and plays a significant role in the initiation and maintenance of inflammation. Upregulation of TNF expression leads to several inflammatory diseases, such as Crohn's,… read more here.
Keywords: affibody; tnfr2 function; tnf; monovalent potency ... See more keywords
Directed Evolution of PD-L1-Targeted Affibodies by mRNA Display.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00218
Abstract: Therapeutic monoclonal antibodies directed against PD-L1 (e.g., atezolizumab) disrupt PD-L1:PD-1 signaling and reactivate exhausted cytotoxic T-cells in the tumor compartment. Although anti-PD-L1 antibodies are successful as immune checkpoint inhibitor (ICI) therapeutics, there is still a… read more here.
Keywords: amino acids; display; affinity; mrna display ... See more keywords
Cytotoxicity evaluation of curcumin-loaded affibody-decorated liposomes against breast cancerous cell lines
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Liposome Research"
DOI: 10.1080/08982104.2020.1755981
Abstract: Abstract Curcumin is known as an effective anticancer herbal medicine but unfortunately, its bioavailability is poor which necessitate efforts for developing more efficient and specific delivery systems. Human epidermal growth factor receptor 2 (HER 2)… read more here.
Keywords: affibody decorated; affibody; cell lines; decorated liposomes ... See more keywords
Izokibep: Preclinical development and first-in-human study of a novel IL-17A neutralizing Affibody molecule in patients with plaque psoriasis
Sign Up to like & getrecommendations! Published in 2023 at "mAbs"
DOI: 10.1080/19420862.2023.2209920
Abstract: ABSTRACT Psoriasis, an immune-mediated inflammatory disease, affects nearly 125 million people globally. The interleukin (IL)-17A homodimer is a key driver of psoriasis and other autoimmune diseases, including psoriatic arthritis, axial spondyloarthritis, hidradenitis suppurativa, and uveitis.… read more here.
Keywords: molecule; affibody; human study; psoriasis ... See more keywords
Radiosynthesis, optimization and pharmacokinetic study of the 99mTc-labeled human epidermal growth factor receptor 2 affibody molecule probe 99mTc-(HE)3ZHER2:V2
Sign Up to like & getrecommendations! Published in 2023 at "Nuclear Medicine Communications"
DOI: 10.1097/mnm.0000000000001660
Abstract: Objective To prepare a single-photon molecular probe easily labeled with 99mTc for evaluating the expression status of the human epidermal growth factor receptor 2 (HER2) receptor in ovarian cancer. Materials and methods The HEHEHE tag… read more here.
Keywords: labeled 99mtc; epidermal growth; human epidermal; affibody ... See more keywords
Novel Affibody Molecules Specifically Bind to SARS-CoV-2 Spike Protein and Efficiently Neutralize Delta and Omicron Variants
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.03562-22
Abstract: SARS-CoV-2 and its variants are threatening the whole world. Although a full dose of vaccine injection showed great preventive effects and monoclonal antibody reagents have also been used for a specific treatment, the global pandemic… read more here.
Keywords: novel affibody; rbmfp; affibody molecules; affibody ... See more keywords
Engineering Saccharomyces cerevisiae for the production and secretion of Affibody molecules
Sign Up to like & getrecommendations! Published in 2022 at "Microbial Cell Factories"
DOI: 10.1186/s12934-022-01761-0
Abstract: Background Affibody molecules are synthetic peptides with a variety of therapeutic and diagnostic applications. To date, Affibody molecules have mainly been produced by the bacterial production host Escherichia coli. There is an interest in exploring… read more here.
Keywords: affibody molecules; saccharomyces cerevisiae; secretion; affibody ... See more keywords