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   Articles with "affibody" as a keyword



In silico approach to probe the binding affinity between OMVs harboring the ZEGFR affibody and the EGF receptor

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recommendations! Published in 2022 at "Journal of Molecular Modeling"

DOI: 10.1007/s00894-022-05043-9

Abstract: There is a growing interest in designing a nanocarrier containing an EGFR targeting affibody to direct toward cancer cells. Here, cytolysin A was cloned at the N-terminus of ZEGFR:1907 affibody to guarantee its surface presentation… read more here.

Keywords: clya affiegfr; affibody; gala; zegfr ... See more keywords

In Vivo Evaluation and Dosimetry Estimate for a High Affinity Affibody PET Tracer Targeting PD-L1

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recommendations! Published in 2020 at "Molecular Imaging and Biology"

DOI: 10.1007/s11307-020-01544-2

Abstract: Purpose In vivo imaging of programmed death ligand 1 (PD-L1) during immunotherapy could potentially monitor changing PD-L1 expression and PD-L1 expression heterogeneity within and across tumors. Some protein constructs can be used for same-day positron… read more here.

Keywords: affibody; affinity; lox; pet tracer ... See more keywords
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Combination of ribosome display and next generation sequencing as a powerful method for identification of affibody binders against β-lactamase CTX-M15.

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recommendations! Published in 2019 at "New biotechnology"

DOI: 10.1016/j.nbt.2019.01.004

Abstract: CTX-M15 is one of the most widespread, extended spectrum β-lactamases, a major determinant of antibiotic resistance representing urgent public health threats, among enterobacterial strains infecting humans and animals. Here we describe the selection of binders… read more here.

Keywords: ctx m15; next generation; affibody; ribosome display ... See more keywords
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Affibody Molecules in Biotechnological and Medical Applications.

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recommendations! Published in 2017 at "Trends in biotechnology"

DOI: 10.1016/j.tibtech.2017.04.007

Abstract: Affibody molecules are small (6.5-kDa) affinity proteins based on a three-helix bundle domain framework. Since their introduction 20 years ago as an alternative to antibodies for biotechnological applications, the first therapeutic affibody molecules have now… read more here.

Keywords: biotechnological medical; affibody; affibody molecules; molecules biotechnological ... See more keywords

Discovery of a Non-competitive TNFR1 Antagonist Affibody with Picomolar Monovalent Potency That Does Not Affect TNFR2 Function.

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recommendations! Published in 2023 at "Molecular pharmaceutics"

DOI: 10.1021/acs.molpharmaceut.2c00385

Abstract: Tumor necrosis factor (TNF) is a key regulator of immune responses and plays a significant role in the initiation and maintenance of inflammation. Upregulation of TNF expression leads to several inflammatory diseases, such as Crohn's,… read more here.

Keywords: affibody; tnfr2 function; tnf; monovalent potency ... See more keywords

Directed Evolution of PD-L1-Targeted Affibodies by mRNA Display.

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recommendations! Published in 2022 at "ACS chemical biology"

DOI: 10.1021/acschembio.2c00218

Abstract: Therapeutic monoclonal antibodies directed against PD-L1 (e.g., atezolizumab) disrupt PD-L1:PD-1 signaling and reactivate exhausted cytotoxic T-cells in the tumor compartment. Although anti-PD-L1 antibodies are successful as immune checkpoint inhibitor (ICI) therapeutics, there is still a… read more here.

Keywords: amino acids; display; affinity; mrna display ... See more keywords

Engineering the Mechanical Stability of a Therapeutic Complex between Affibody and Programmed Death-Ligand 1 by Anchor Point Selection.

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recommendations! Published in 2024 at "ACS nano"

DOI: 10.1021/acsnano.4c09220

Abstract: Protein-protein complexes can vary in mechanical stability depending on the direction from which force is applied. Here, we investigated the mechanical stability of a complex between a binding scaffold called Affibody and an immune checkpoint… read more here.

Keywords: mechanical stability; programmed death; affibody; point ... See more keywords

DGCR2 targeting affibody molecules for delivery of drugs and imaging reagents to human beta cells

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-024-84574-y

Abstract: A distinctive feature of both type 1 and type 2 diabetes is the waning of insulin-secreting beta cells in the pancreas. New methods for direct and specific targeting of the beta cells could provide platforms… read more here.

Keywords: affibody; delivery; imaging reagents; beta ... See more keywords

Cytotoxicity evaluation of curcumin-loaded affibody-decorated liposomes against breast cancerous cell lines

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recommendations! Published in 2020 at "Journal of Liposome Research"

DOI: 10.1080/08982104.2020.1755981

Abstract: Abstract Curcumin is known as an effective anticancer herbal medicine but unfortunately, its bioavailability is poor which necessitate efforts for developing more efficient and specific delivery systems. Human epidermal growth factor receptor 2 (HER 2)… read more here.

Keywords: affibody decorated; affibody; cell lines; decorated liposomes ... See more keywords

Izokibep: Preclinical development and first-in-human study of a novel IL-17A neutralizing Affibody molecule in patients with plaque psoriasis

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recommendations! Published in 2023 at "mAbs"

DOI: 10.1080/19420862.2023.2209920

Abstract: ABSTRACT Psoriasis, an immune-mediated inflammatory disease, affects nearly 125 million people globally. The interleukin (IL)-17A homodimer is a key driver of psoriasis and other autoimmune diseases, including psoriatic arthritis, axial spondyloarthritis, hidradenitis suppurativa, and uveitis.… read more here.

Keywords: molecule; affibody; human study; psoriasis ... See more keywords

Radiosynthesis, optimization and pharmacokinetic study of the 99mTc-labeled human epidermal growth factor receptor 2 affibody molecule probe 99mTc-(HE)3ZHER2:V2

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recommendations! Published in 2023 at "Nuclear Medicine Communications"

DOI: 10.1097/mnm.0000000000001660

Abstract: Objective To prepare a single-photon molecular probe easily labeled with 99mTc for evaluating the expression status of the human epidermal growth factor receptor 2 (HER2) receptor in ovarian cancer. Materials and methods The HEHEHE tag… read more here.

Keywords: labeled 99mtc; epidermal growth; human epidermal; affibody ... See more keywords