Proteome‐Wide Identification of On‐ and Off‐Targets of Bcl‐2 Inhibitors in Native Biological Systems by Using Affinity‐Based Probes (AfBPs)
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201800380
Abstract: Selective inhibition of proteins of the Bcl‐2 family by small‐molecule inhibitors is a promising new approach in drug discovery. However, information about how these molecules interact with their cellular targets (on‐ and off‐) is highly… read more here.
Keywords: probes afbps; targets bcl; bcl inhibitors; affinity based ... See more keywords
Affinity-Based Enrichment Techniques for the Genome-Wide Analysis of 5-Hydroxymethylcytosine.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7481-8_35
Abstract: Since its initial characterization in 2009 there has been a great degree of interest in comparative profiling of 5-hydroxymethylcytosine (5hmC) nucleotides in vertebrate DNA. Through a host of genome-wide studies the distribution of 5hmC has… read more here.
Keywords: genome wide; enrichment; affinity; wide analysis ... See more keywords
Current trends in affinity-based monoliths in microextraction approaches: A review.
Sign Up to like & getrecommendations! Published in 2019 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2019.07.020
Abstract: This article reviews the research contributions along the past five years concerning to monolithic materials for the development of affinity-based sorbents in the field of microextraction techniques. The first part of this paper includes an… read more here.
Keywords: current trends; trends affinity; microextraction; affinity ... See more keywords
Release Kinetics from Nano-Inclusion-Based and Affinity-Based Hydrogels: A Comparative Study
Sign Up to like & getrecommendations! Published in 2017 at "Colloids and Surfaces A: Physicochemical and Engineering Aspects"
DOI: 10.1016/j.colsurfa.2017.05.089
Abstract: Abstract In this study, we compare the release mechanisms from nanocomposite hydrogels. Liposomes made of different compositions of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine (DPPC), nanogels made of chitosan-hyaluronic acid association and crosslinked nanogels made of N-isopropylacrylamide… read more here.
Keywords: release kinetics; release mechanisms; study; affinity based ... See more keywords
Mesofossils with noeggerathialean affinity based on epidermal characteristics from the Mississippian (lower Carboniferous) of Gansu Province, northwestern China
Sign Up to like & getrecommendations! Published in 2021 at "Review of Palaeobotany and Palynology"
DOI: 10.1016/j.revpalbo.2021.104432
Abstract: Abstract Three types of charcoalified mesofossils with anatomical structures are described from the Serpkhovian (Carboniferous) Jingyuan Formation in northwestern China. They are characterized by fragmental pinnules with apical teeth, dentate lateral margins, and simple stomatal… read more here.
Keywords: stomatal apparati; northwestern china; china; noeggerathialean affinity ... See more keywords
Coordination Affinity of Cu(II)-Based Silsesquioxanes toward N,N-Ligands and Associated Skeletal Rearrangements: Cage and Ionic Products Exhibiting a High Catalytic Activity in Oxidation Reactions.
Sign Up to like & getrecommendations! Published in 2020 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.9b03680
Abstract: An unusual skeletal rearrangement of piperazine into ethylenediamine has been observed for the first time as a result of an attempt to synthesize a piperazine-linked metal-organic framework (MOF) using cage Cu(II),Na-phenylsilsequixane as a potential building… read more here.
Keywords: based silsesquioxanes; ionic products; oxidation; coordination affinity ... See more keywords
Affinity-Based Profiling of the Flavin Mononucleotide Riboswitch
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c02685
Abstract: Riboswitches are structural RNA elements that control gene expression. These naturally occurring RNA sensors are of continued interest as antibiotic targets, molecular sensors, and functional elements of synthetic circuits. Here, we describe affinity-based profiling of… read more here.
Keywords: fmn riboswitch; riboswitch; affinity based; based profiling ... See more keywords
Competitive affinity-based proteome profiling and imaging to reveal potential cellular targets of betulinic acid.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc04190j
Abstract: Betulinic acid (BA), a pentacyclic triterpenoid natural product, has received considerable attention owing to the broad spectrum of biological activities such as anti-HIV, anti-inflammatory, and especially, antitumor. Despite numerous studies on the antitumor mechanisms over… read more here.
Keywords: potential cellular; competitive affinity; proteome profiling; betulinic acid ... See more keywords
Identification of mitochondrial proteins associated with cyanine 5 using a combination of affinity-based photocrosslinking with bio-orthogonal supramolecular latching
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Porphyrins and Phthalocyanines"
DOI: 10.1142/s108842462350058x
Abstract: Visualization of mitochondria with cyanine dyes has been exploited to study the functions of mitochondria. However, proteins interacting with cyanine dyes have not been investigated clearly. Here, we report a chemical proteomics approach for the… read more here.
Keywords: proteins associated; based photocrosslinking; identification mitochondrial; mitochondrial proteins ... See more keywords
‘Creating the community I want to be part of’: Affinity-based organising in a small, progressive rustbelt city
Sign Up to like & getrecommendations! Published in 2021 at "Urban Studies"
DOI: 10.1177/0042098020966258
Abstract: This article explores a small city’s response to the inauguration of Donald Trump in January 2017. Love, Resilience, Action Ypsilanti (LRAY) focused on community-building and the social justice history of Ypsilanti, Michigan to create a… read more here.
Keywords: city; progressive rustbelt; rustbelt city; community ... See more keywords
Anion Exchange Affinity-Based Controllable Surface Imprinting Synthesis of Ultrathin Imprinted Films for Protein Recognition
Sign Up to like & getrecommendations! Published in 2022 at "Polymers"
DOI: 10.3390/polym14102011
Abstract: Anion exchange affinity-based controllable surface imprinting is an effective approach to overcome low imprinting efficiency and high non-specific binding capacity. The template proteins were first immobilized on the anchored tetraalkylammonium groups of the nanoparticles via… read more here.
Keywords: exchange affinity; exchange; imprinted films; anion exchange ... See more keywords