High affinity binding of amyloid β-peptide to calmodulin: Structural and functional implications.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.03.151
Abstract: Amyloid β-peptides (Aβ) are a major hallmark of Alzheimer's disease (AD) and their neurotoxicity develop with cytosolic calcium dysregulation. On the other hand, calmodulin (CaM), a protein which plays a major multifunctional role in neuronal… read more here.
Keywords: cam; affinity binding; high affinity; affinity ... See more keywords
Exploring high-affinity binding properties of octamer peptides by principal component analysis of tetramer peptides.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of bioscience and bioengineering"
DOI: 10.1016/j.jbiosc.2016.08.005
Abstract: To investigate the binding properties of a peptide sequence, we conducted principal component analysis (PCA) of the physicochemical features of a tetramer peptide library comprised of 512 peptides, and the variables were reduced to two… read more here.
Keywords: high affinity; affinity; principal component; tetramer ... See more keywords
Articular cartilage regeneration using acellular bioactive affinity-binding alginate hydrogel: A 6-month study in a mini-pig model of osteochondral defects
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Orthopaedic Translation"
DOI: 10.1016/j.jot.2018.08.003
Abstract: Background Despite intensive research, regeneration of articular cartilage largely remains an unresolved medical concern as the clinically available modalities still suffer from long-term inconsistent data, relatively high failure rates and high prices of more promising… read more here.
Keywords: binding alginate; affinity; affinity binding; alginate hydrogel ... See more keywords
Immobilization of unspecific peroxygenase expressed in Pichia pastoris by metal affinity binding
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Catalysis"
DOI: 10.1016/j.mcat.2020.110999
Abstract: Abstract Unspecific peroxygenases (UPOs) catalyze oxidation and oxygenation reactions using only hydrogen peroxide as a co-substrate. Especially their ability to oxygenate unactivated C–H bonds has attracted interest in their synthetic application. Due to the high… read more here.
Keywords: metal affinity; immobilization; pichia pastoris; affinity binding ... See more keywords
Structural Insights into the Mechanism of High-Affinity Binding of Ochratoxin A by a DNA Aptamer.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c00478
Abstract: A 36-mer guanine (G)-rich DNA aptamer (OBA36) is able to distinguish one atomic difference between ochratoxin analogues A (OTA) and B (OTB), showing prominent recognition specificity and affinity among hundreds of aptamers for small molecules.… read more here.
Keywords: dna aptamer; high affinity; affinity; affinity binding ... See more keywords
High-affinity binding at quadruplex–duplex junctions: rather the rule than the exception
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1088
Abstract: Abstract Quadruplex-duplex (Q–D) junctions constitute unique structural motifs in genomic sequences. Through comprehensive calorimetric as well as high-resolution NMR structural studies, Q–D junctions with a hairpin-type snapback loop coaxially stacked onto an outer G-tetrad were… read more here.
Keywords: quadruplex duplex; high affinity; selectivity; duplex junctions ... See more keywords