In silicopost-SELEX screening and experimental characterizations for acquisition of high affinity DNA aptamers against carcinoembryonic antigen
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DOI: 10.1039/c8ra10163a
Abstract: High affinity DNA aptamers against carcinoembryonic antigen were selected and verified by using anin silicoapproach and experimental characterizations. read more here.
Keywords: carcinoembryonic antigen; dna aptamers; experimental characterizations; affinity dna ... See more keywords
Unexpected moves: a conformational change in MutSĪ± enables high-affinity DNA mismatch binding
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad015
Abstract: Abstract The DNA mismatch repair protein MutSĪ± recognizes wrongly incorporated DNA bases and initiates their correction during DNA replication. Dysfunctions in mismatch repair lead to a predisposition to cancer. Here, we study the homozygous mutation… read more here.
Keywords: mismatch binding; affinity dna; dna; high affinity ... See more keywords