Introduction of an Aldehyde Handle on Nanobodies by Affinity-Guided Labeling.
Sign Up to like & getrecommendations! Published in 2020 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.0c00151
Abstract: Chemically modified antigen-binding proteins are widely applied for their targeting abilities in the fields of biotechnol-ogy, medicine and diagnostics. However, the production of site-selectively modified proteins remains a challenge. Here, we have designed a chemical… read more here.
Keywords: aldehyde handle; introduction; introduction aldehyde; affinity guided ... See more keywords
Affinity-Guided Conjugation to Antibodies for Use in Positron Emission Tomography.
Sign Up to like & getrecommendations! Published in 2019 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.9b00013
Abstract: The radionuclide copper-64 is widely used in combination with biomolecules, such as antibodies, for positron emission tomography (PET). Copper-64 is ideal for the imaging of biomolecules with long circulation times due to its relatively long… read more here.
Keywords: guided conjugation; affinity guided; affinity; copper ... See more keywords
Abstract 751: A controlled affinity-guided ADC-linker (MAGNET) technology
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-751
Abstract: Antibody-drug conjugates (ADCs) have emerged as a powerful technology in cancer therapy. However, challenges with current linker technologies have limited the repertoire of ADCs. Currently-used linkers result in a heterogeneous mixture, unstable conjugates and/or involve… read more here.
Keywords: affinity guided; affinity; magnet; linker ... See more keywords