Kindlin-3 recruitment to the plasma membrane precedes high affinity β2 integrin and neutrophil arrest from rolling.
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DOI: 10.1182/blood.2019003446
Abstract: Integrin-mediated neutrophil adhesion starts by arrest from rolling. Activation of integrins involves conformational changes from an inactive bent conformation to an extended conformation (E+) with high affinity for ligand binding (H+). The cytoplasmic protein kindlin-3… read more here.
Keywords: affinity integrin; high affinity; plasma membrane; kindlin ... See more keywords