Alternative Affinity Ligands for Immunoglobulins.
Sign Up to like & getrecommendations! Published in 2017 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.7b00335
Abstract: The demand for recombinant therapeutic antibodies and Fc-fusion proteins is expected to increase in the years to come. Hence, extensive efforts are concentrated on improving the downstream processing. In particular, the development of better-affinity chromatography… read more here.
Keywords: affinity ligands; ligands immunoglobulins; binding proteins; affinity ... See more keywords
Allosteric Modulation of Membrane Proteins by Small Low-Affinity Ligands
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c01542
Abstract: Membrane proteins may respond to a variety of ligands under an applied external stimulus. These ligands include small low-affinity molecules that account for functional effects in the mM range. Understanding the modulation of protein function… read more here.
Keywords: membrane proteins; affinity; low affinity; affinity ligands ... See more keywords
IgG Fc Affinity Ligands and Their Applications in Antibody-Involved Drug Delivery: A Brief Review
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DOI: 10.3390/pharmaceutics15010187
Abstract: Antibodies are not only an important class of biotherapeutic drugs, but also are targeting moieties for achieving active targeting drug delivery. Meanwhile, the rapidly increasing application of antibodies and Fc-fusion proteins has inspired the emerging… read more here.
Keywords: drug delivery; drug; affinity ligands; antibody ... See more keywords