Peptide-to-Small Molecule: A Pharmacophore-Guided Small Molecule Lead Generation Strategy from High-Affinity Macrocyclic Peptides.
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DOI: 10.1021/acs.jmedchem.2c00919
Abstract: Recent technological innovations have led to the development of methods for the rapid identification of high-affinity macrocyclic peptides for a wide range of targets; however, it is still challenging to achieve the desired activity and… read more here.
Keywords: small molecule; macrocyclic peptides; high affinity; molecule ... See more keywords