Isolation of an in Vitro Affinity-Matured, Thermostable "Headless" HA Stem Fragment That Binds Broadly Neutralizing Antibodies with High Affinity.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00267
Abstract: The surface glycoprotein hemagglutinin (HA) of influenza virus is the primary target for the design of an effective universal influenza vaccine as it is capable of eliciting broadly cross-reactive antibodies against different HA subtypes. Several… read more here.
Keywords: affinity; affinity matured; isolation vitro; neutralizing antibodies ... See more keywords
Vaccination of SARS-CoV-2-infected individuals expands a broad range of clonally diverse affinity-matured B cell lineages
Sign Up to like & getrecommendations! Published in 2023 at "Nature Communications"
DOI: 10.21203/rs.3.rs-2231608/v1
Abstract: Here, the authors isolated and characterized genetic features of spike-specific monoclonal antibodies. They show how the antibodies evolve from infection to after vaccination and conclude that highly polyclonal repertoires of affinity-matured memory B cells are… read more here.
Keywords: affinity matured; vaccination sars; vaccination; broad range ... See more keywords