High-Throughput Affinity Measurements of Transcription Factor and DNA Mutations Reveal Affinity and Specificity Determinants.
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DOI: 10.1016/j.cels.2020.11.012
Abstract: Transcription factors (TFs) bind regulatory DNA to control gene expression, and mutations to either TFs or DNA can alter binding affinities to rewire regulatory networks and drive phenotypic variation. While studies have profiled energetic effects… read more here.
Keywords: dna mutations; dna; affinity; affinity measurements ... See more keywords