Generating Biologically Stable TNA Aptamers that Function with High Affinity and Thermal Stability.
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DOI: 10.1021/jacs.0c00641
Abstract: Aptamers generated from natural and modified nucleo-tides are often prone to nuclease digestion, which limits their utility in many biomedical applications, including therapeutics. Here we describe the in vitro selection of an unnatural nucleic acid… read more here.
Keywords: affinity thermal; tna aptamers; tna; thermal stability ... See more keywords