p55PIK regulates alpha‐fetoprotein expression through the NF‐&kgr;B signaling pathway
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.09.043
Abstract: Aims: Alpha‐fetoprotein (AFP) is regarded as a diagnostic and prognostic biomarker and a potential therapeutic target for hepatocellular carcinoma (HCC). However, the regulation of AFP expression in HCC remains poorly understood. This study aimed to… read more here.
Keywords: kgr signaling; signaling pathway; expression; afp expression ... See more keywords
Cellular gp96 upregulates AFP expression by blockade of NR5A2 SUMOylation and ubiquitination in HCC.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of molecular cell biology"
DOI: 10.1093/jmcb/mjad027
Abstract: AFP is the most widely used biomarker for the diagnosis of hepatocellular carcinoma. However, a substantial proportion of HCC patients have either normal or marginally increased AFP levels in serum, and the underlying mechanisms are… read more here.
Keywords: afp expression; hcc; sumoylation ubiquitination; gp96 ... See more keywords
Improving the Detection of Hepatocellular Carcinoma Using Serum AFP Expression in Combination with GPC3 and Micro-RNA MiR-122 Expression
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DOI: 10.1515/biol-2019-0007
Abstract: Abstract Early diagnosis of hepatocellular carcinoma (HCC) greatly improves the survival and prognosisfor patients. In this study weevaluate the diagnostic promise of combining serum alpha-fetoprotein (AFP) expression with two potential biomarkers, serum glypican-3 (GPC3) and… read more here.
Keywords: hcc; expression; mir 122; afp expression ... See more keywords