APOL1 Risk Variants, Acute Kidney Injury, and Death in Participants With African Ancestry Hospitalized With COVID-19 From the Million Veteran Program.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2021.8538
Abstract: Importance Coronavirus disease 2019 (COVID-19) confers significant risk of acute kidney injury (AKI). Patients with COVID-19 with AKI have high mortality rates. Objective Individuals with African ancestry with 2 copies of apolipoprotein L1 (APOL1) variants… read more here.
Keywords: risk; ancestry; risk group; risk variants ... See more keywords
Impact of African ancestry on the relationship between body mass index and survival in an early‐stage breast cancer trial (ECOG‐ACRIN E5103)
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DOI: 10.1002/cncr.34173
Abstract: African ancestry (AA) and obesity are associated with worse survival in early‐stage breast cancer. Obesity disproportionately affects women of AA; however, the intersection between ancestry and obesity on breast cancer outcomes remains unclear. read more here.
Keywords: breast cancer; survival early; african ancestry; cancer ... See more keywords
Association of HPV35 with cervical carcinogenesis among women of African ancestry: Evidence of viral‐host interaction with implications for disease intervention
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Cancer"
DOI: 10.1002/ijc.33033
Abstract: HPV35 has been found in only ∼2% of invasive cervical cancers (ICC) worldwide but up to 10% in Sub‐Saharan Africa, warranting further investigation and consideration of impact on preventive strategies. We studied HPV35 and ethnicity,… read more here.
Keywords: african ancestry; cervical carcinogenesis; hpv35; hpv35 cervical ... See more keywords
Trans-ethnic variation in germline variants of patients with renal cell carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.108926
Abstract: Prior studies of the renal cell carcinoma (RCC) germline landscape investigated predominantly patients of European ancestry. We examine the frequency of germline pathogenic and likely pathogenic (P/LP) variants in 1,829 patients with RCC from various… read more here.
Keywords: renal cell; cell carcinoma; african ancestry; germline ... See more keywords
Towards diversity in genomics: The emergence of neurogenomics in Africa?
Sign Up to like & getrecommendations! Published in 2018 at "Genomics"
DOI: 10.1016/j.ygeno.2017.07.009
Abstract: There is a high burden of mental and neurological disorders in Africa. Nevertheless, there appears to be an under-representation of African ancestry populations in large-scale genomic studies. Here, we evaluated the extent of under-representation of… read more here.
Keywords: towards diversity; african ancestry; diversity genomics; ancestry ... See more keywords
Strong selection during the last millennium for African ancestry in the admixed population of Madagascar
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03342-5
Abstract: While admixed populations offer a unique opportunity to detect selection, the admixture in most of the studied populations occurred too recently to produce conclusive signals. By contrast, Malagasy populations originate from admixture between Asian and… read more here.
Keywords: ancestry; population madagascar; selection; african ancestry ... See more keywords
Rare coding variants associated with blood pressure variation in 15 914 individuals of African ancestry
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Hypertension"
DOI: 10.1097/hjh.0000000000001319
Abstract: Objectives: Hypertension is a major risk factor for all cardiovascular diseases, especially among African Americans. This study focuses on identifying specific blood pressure (BP) genes using 15 914 individuals of African ancestry from eight cohorts (Africa… read more here.
Keywords: blood pressure; african ancestry; 914 individuals; individuals african ... See more keywords
Apolipoprotein L1: role in the evaluation of kidney transplant donors
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Nephrology and Hypertension"
DOI: 10.1097/mnh.0000000000000653
Abstract: Purpose of review To summarize the current state of evidence regarding the role of apolipoprotein L1 (APOL1) genotyping in evaluating donors for kidney transplantation. Recent findings African ancestry is associated with an increased risk of… read more here.
Keywords: high risk; role; african ancestry; evaluation ... See more keywords
Obesity and diabetes in people of African ancestry with HIV
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DOI: 10.1111/hiv.13413
Abstract: Obesity is a chronic disease with multiple adverse effects on health. The prevalence of obesity is increasing worldwide, and people of African ancestry are disproportionally affected. Several widely used antiretrovirals have been associated with weight… read more here.
Keywords: obesity diabetes; weight gain; obesity; people african ... See more keywords
Under‐representation of people of African ancestry in publications on the cutaneous manifestations of COVID‐19: coincidence or physiology?
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.17289
Abstract: Recent publications have highlighted the rarity of patients with dark skin amongst Covid19-related skin eruptions.1 Indeed, very few patients of non-European descent were reported amongst 318 cases of Covid19-related perniosis 2 and there was a… read more here.
Keywords: african ancestry; physiology; representation people; people african ... See more keywords
Impact of societal and legal context on the blood supply of African‐ancestry populations in Western countries: A review of practices and the French example
Sign Up to like & getrecommendations! Published in 2022 at "Vox Sanguinis"
DOI: 10.1111/vox.13326
Abstract: In Western countries, blood supply agencies encounter impediments in providing blood groups defined as rare or of interest, notably for sub‐Saharan African ancestry (SSAA) recipients. To establish warning levels and anticipate future blood needs, an… read more here.
Keywords: blood; western countries; african ancestry; blood supply ... See more keywords