Validity of the SNAP-IV For ADHD Assessment in South African Children With Neurodevelopmental Disorders.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of autism and developmental disorders"
DOI: 10.1007/s10803-022-05530-1
Abstract: This study investigated the psychometric properties of the Swanson, Nolan, and Pelham ADHD Rating Scale (SNAP-IV) in a sample of South African children with neurodevelopmental disorders (n = 201), primarily Autism Spectrum Disorder and Intellectual Disability. We… read more here.
Keywords: african children; children neurodevelopmental; south african; validity snap ... See more keywords
Cultural variation in cognitive flexibility reveals diversity in the development of executive functions
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DOI: 10.1038/s41598-018-34756-2
Abstract: Cognitive flexibility, the adaptation of representations and responses to new task demands, improves dramatically in early childhood. It is unclear, however, whether flexibility is a coherent, unitary cognitive trait, or is an emergent dimension of… read more here.
Keywords: rule switching; flexibility; south african; word learning ... See more keywords
Population pharmacokinetics of ethambutol in African children: a pooled analysis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkac127
Abstract: Abstract Objectives Ethambutol protects against the development of resistance to co-administered drugs in the intensive phase of first-line anti-TB treatment in children. It is especially relevant in settings with a high prevalence of HIV or… read more here.
Keywords: lopinavir ritonavir; pharmacokinetics ethambutol; ethambutol african; population pharmacokinetics ... See more keywords
Pharmacokinetics of once-daily darunavir/ritonavir in second-line treatment in African children with HIV
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DOI: 10.1093/jac/dkae319
Abstract: Abstract Background Darunavir is a potent HIV protease inhibitor with a high barrier to resistance. We conducted a nested pharmacokinetic sub-study within CHAPAS-4 to evaluate darunavir exposure in African children with HIV, taking once-daily darunavir/ritonavir… read more here.
Keywords: african children; darunavir; ritonavir second; children hiv ... See more keywords
Effect of diurnal variation, CYP2B6 genotype and age on the pharmacokinetics of nevirapine in African children
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DOI: 10.1093/jac/dkw388
Abstract: Objectives To characterize the effects of CYP2B6 polymorphisms, diurnal variation and demographic factors on nevirapine pharmacokinetics in African children. Methods Non-linear mixed-effects modelling conducted in NONMEM 7.3 described nevirapine plasma concentration–time data from 414 children… read more here.
Keywords: cyp2b6; effect; metabolizer; diurnal variation ... See more keywords
Haematological cancers in African children: progress and challenges
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Haematology"
DOI: 10.1111/bjh.14617
Abstract: Cancer is increasingly important in low and middle‐income settings where infectious diseases are declining. Childhood cancers treated in well‐resourced centres have excellent outcomes with more than 80% survival. This success is not reflected in low‐income… read more here.
Keywords: progress challenges; haematological cancers; children progress; cancers african ... See more keywords
Normal values of respiratory oscillometry in South African children and adolescents
Sign Up to like & getrecommendations! Published in 2023 at "ERJ Open Research"
DOI: 10.1183/23120541.00371-2022
Abstract: Introduction Noninvasive measurement of respiratory impedance by oscillometry can be used in young children aged from 3 years and those unable to perform forced respiratory manoeuvres. It can discriminate between healthy children and those with respiratory… read more here.
Keywords: african children; reference equations; oscillometry; children adolescents ... See more keywords
Prevalence and predictors of vitamin D deficiency in young African children
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DOI: 10.1186/s12916-021-01985-8
Abstract: Children living in sub-Saharan Africa have a high burden of rickets and infectious diseases, conditions that are linked to vitamin D deficiency. However, data on the vitamin D status of young African children and its… read more here.
Keywords: young african; prevalence; deficiency young; deficiency ... See more keywords
Azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a phase II randomised controlled trial
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DOI: 10.1186/s12916-024-03712-5
Abstract: African children with severe malaria are at increased risk of non-typhoidal salmonellae co-infection. Broad-spectrum antibiotics are recommended by guidelines but the optimal class and dose have not been established. We investigated the optimal dose of… read more here.
Keywords: african children; bacterial infection; severe malaria; infection ... See more keywords
Pharmacokinetics and pharmacodynamics of azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a protocol for a Phase II randomised controlled trial
Sign Up to like & getrecommendations! Published in 2021 at "Wellcome Open Research"
DOI: 10.12688/wellcomeopenres.16968.1
Abstract: Background: African children with severe malaria are susceptible to Gram-negative bacterial co-infection, largely non-typhoidal Salmonellae, leading to a substantially higher rates of in-hospital and post-discharge mortality than those without bacteraemia. Current evidence for treating co-infection… read more here.
Keywords: phase; bacterial infection; trial; infection ... See more keywords
Bronchiectasis in African children: Challenges and barriers to care
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2022.954608
Abstract: Bronchiectasis (BE) is a chronic condition affecting the bronchial tree. It is characterized by the dilatation of large and medium-sized airways, secondary to damage of the underlying bronchial wall structural elements and accompanied by the… read more here.
Keywords: bronchiectasis african; children challenges; management; african children ... See more keywords