Infection of the maternal-fetal interface and vertical transmission following low-dose inoculation of pregnant rhesus macaques (Macaca mulatta) with an African-lineage Zika virus
Sign Up to like & getrecommendations! Published in 2022 at "PLOS ONE"
DOI: 10.1101/2022.05.16.492053
Abstract: Background Congenital Zika virus (ZIKV) infection can result in birth defects, including malformations in the fetal brain and visual system. There are two distinct genetic lineages of ZIKV: African and Asian. Asian lineage ZIKVs have… read more here.
Keywords: infection; virus; african lineage; zikv ... See more keywords
African-Lineage Zika Virus Replication Dynamics and Maternal-Fetal Interface Infection in Pregnant Rhesus Macaques
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Virology"
DOI: 10.1128/jvi.02220-20
Abstract: ZIKV was first identified in 1947 in Africa, but most of our knowledge of ZIKV is based on studies of the distinct Asian genetic lineage, which caused the outbreak in the Americas in 2015 to… read more here.
Keywords: lineage; pregnant rhesus; african lineage; lineage isolates ... See more keywords
Fetal loss in pregnant rhesus macaques infected with high-dose African-lineage Zika virus
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0010623
Abstract: Countermeasures against Zika virus (ZIKV), including vaccines, are frequently tested in nonhuman primates (NHP). Macaque models are important for understanding how ZIKV infections impact human pregnancy due to similarities in placental development. The lack of… read more here.
Keywords: lineage zikv; loss; african lineage; zikv ... See more keywords