Genetic structure and sex‐biased gene flow in the history of southern African populations
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Physical Anthropology"
DOI: 10.1002/ajpa.23694
Abstract: Abstract Objectives We investigated the genetic history of southern African populations with a special focus on their paternal history. We reexamined previous claims that the Y‐chromosome haplogroup E1b1b (E‐M293) was brought to southern Africa by… read more here.
Keywords: southern african; sex biased; history; history southern ... See more keywords
New Insight into the human genetic diversity in North African populations by genotyping of SNPs in DRD3 , CSMD1 and NRG1 genes
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1871
Abstract: The single nucleotide polymorphisms (SNPs) of the dopamine D3 receptor (DRD3), the CUB and sushi multiple domains 1 (CSMD1) and the neuregulin 1 (NRG1) genes were used to study the genetic diversity and affinity among… read more here.
Keywords: genetic diversity; drd3; african populations; north african ... See more keywords
Molecular dynamics of G6PD variants from sub-Saharan Africa
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2022.101236
Abstract: Precision medicine uses genomic guidance to improve drug treatment safety and efficacy. Prior knowledge of genetic variant impact can enable such strategies, but current knowledge of African variants remains scarce. G6PD variants are linked to… read more here.
Keywords: precision medicine; g6pd variants; medicine; african populations ... See more keywords
Consumption of processed food dietary patterns in four African populations
Sign Up to like & getrecommendations! Published in 2018 at "Public Health Nutrition"
DOI: 10.1017/s136898001700386x
Abstract: Abstract Objective To identify predominant dietary patterns in four African populations and examine their association with obesity. Design Cross-sectional study. Setting/Subjects We used data from the Africa/Harvard School of Public Health Partnership for Cohort Research… read more here.
Keywords: patterns four; four african; diet pattern; dietary patterns ... See more keywords
Whole-genome sequencing for an enhanced understanding of genetic variation among South Africans
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00663-9
Abstract: The Southern African Human Genome Programme is a national initiative that aspires to unlock the unique genetic character of southern African populations for a better understanding of human genetic diversity. In this pilot study the… read more here.
Keywords: whole genome; southern african; southeastern bantu; genome sequencing ... See more keywords
Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-25213-2
Abstract: The human gut microbiota is increasingly recognized as an important factor in modulating innate and adaptive immunity through release of ligands and metabolites that translocate into circulation. Urbanizing African populations harbor large intestinal diversity due… read more here.
Keywords: rural urban; mediated metabolism; microbiome mediated; gut microbiome ... See more keywords
Genetic Diversity in Drug Transporters: Impact in African Populations
Sign Up to like & getrecommendations! Published in 2020 at "Clinical and Translational Science"
DOI: 10.1111/cts.12769
Abstract: Polymorphisms in drug transporters, like the adenosine triposphate‒binding cassette (ABC) and solute carrier (SLC) superfamilies, may contribute to the observed diversity in drug response in African patients. This review aims to provide a comprehensive summary… read more here.
Keywords: genetic diversity; diversity drug; drug; drug transporters ... See more keywords
African evolutionary history inferred from whole genome sequence data of 44 indigenous African populations
Sign Up to like & getrecommendations! Published in 2019 at "Genome Biology"
DOI: 10.1186/s13059-019-1679-2
Abstract: BackgroundAfrica is the origin of modern humans within the past 300 thousand years. To infer the complex demographic history of African populations and adaptation to diverse environments, we sequenced the genomes of 92 individuals from… read more here.
Keywords: indigenous african; geography; lineages diverged; history ... See more keywords
A review of clinical pharmacogenetics Studies in African populations
Sign Up to like & getrecommendations! Published in 2020 at "Personalized medicine"
DOI: 10.2217/pme-2019-0110
Abstract: Effective interventions and treatments for complex diseases have been implemented globally, however, coverage in Africa has been comparatively lower due to lack of capacity, clinical applicability and knowledge on the genetic contribution to disease and… read more here.
Keywords: medicine; pharmacogenetics studies; studies african; review clinical ... See more keywords
Systematic Review of Genetic Factors in the Etiology of Esophageal Squamous Cell Carcinoma in African Populations
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2019.00642
Abstract: Background: Esophageal squamous cell carcinoma (ESCC), one of the most aggressive cancers, is endemic in Sub-Saharan Africa, constituting a major health burden. It has the most divergence in cancer incidence globally, with high prevalence reported… read more here.
Keywords: etiology; cell carcinoma; squamous cell; genetic factors ... See more keywords
High Resolution HLA ∼A, ∼B, ∼C, ∼DRB1, ∼DQA1, and ∼DQB1 Diversity in South African Populations
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.711944
Abstract: Background: Lack of HLA data in southern African populations hampers disease association studies and our understanding of genetic diversity in these populations. We aimed to determine HLA diversity in South African populations using high resolution… read more here.
Keywords: hla; high resolution; african populations; resolution hla ... See more keywords