Innate immunity in the tsetse fly (Glossina), vector of African trypanosomes.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2019.05.003
Abstract: Tsetse flies (Glossina sp.) are medically and veterinary important vectors of African trypanosomes, protozoan parasites that cause devastating diseases in humans and livestock in sub-Saharan Africa. These flies feed exclusively on vertebrate blood and harbor… read more here.
Keywords: immunity tsetse; fly glossina; glossina vector; african trypanosomes ... See more keywords
Quorum sensing in African trypanosomes.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in microbiology"
DOI: 10.1016/j.mib.2019.07.001
Abstract: Many microbial eukaryotes exhibit cell-cell communication to co-ordinate group behaviours as a strategy to exploit a changed environment, adapt to adverse conditions or regulate developmental responses. Although best characterised in bacteria, eukaryotic microbes have also… read more here.
Keywords: quorum sensing; african trypanosomes; sensing african; microbiology ... See more keywords
CRISPR/Cas9-based precision tagging of essential genes in bloodstream form African trypanosomes.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular and biochemical parasitology"
DOI: 10.1016/j.molbiopara.2022.111476
Abstract: Proteins of interest are frequently expressed with a fusion-tag to facilitate experimental analysis. In trypanosomatids, which are typically diploid, a tag-encoding DNA fragment is typically fused to one native allele. However, since recombinant cells represent… read more here.
Keywords: bloodstream form; african trypanosomes; cas9 based; form african ... See more keywords
Evolution of the variant surface glycoprotein family in African trypanosomes.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in parasitology"
DOI: 10.1016/j.pt.2021.07.012
Abstract: An intriguing and remarkable feature of African trypanosomes is their antigenic variation system, mediated by the variant surface glycoprotein (VSG) family and fundamental to both immune evasion and disease epidemiology within host populations. Recent studies… read more here.
Keywords: surface glycoprotein; variant surface; family; evolution variant ... See more keywords
APOLs with low pH dependence can kill all African trypanosomes
Sign Up to like & getrecommendations! Published in 2017 at "Nature microbiology"
DOI: 10.1038/s41564-017-0034-1
Abstract: The primate-specific serum protein apolipoprotein L1 (APOL1) is the only secreted member of a family of cell death promoting proteins1–4. APOL1 kills the bloodstream parasite Trypanosoma brucei brucei, but not the human sleeping sickness agents… read more here.
Keywords: dependence; apols low; brucei; african trypanosomes ... See more keywords
Common and unique features of glycosylation and glycosyltransferases in African trypanosomes
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Journal"
DOI: 10.1042/bcj20210778
Abstract: Eukaryotic protein glycosylation is mediated by glycosyl- and oligosaccharyl-transferases. Here, we describe how African trypanosomes exhibit both evolutionary conservation and significant divergence compared with other eukaryotes in how they synthesise their glycoproteins. The kinetoplastid parasites… read more here.
Keywords: african trypanosomes; features glycosylation; glycosyltransferases african; glycosylation glycosyltransferases ... See more keywords
Pathogenicity and virulence of African trypanosomes: From laboratory models to clinically relevant hosts
Sign Up to like & getrecommendations! Published in 2022 at "Virulence"
DOI: 10.1080/21505594.2022.2150445
Abstract: ABSTRACT African trypanosomes are vector-borne protozoa, which cause significant human and animal disease across sub-Saharan Africa, and animal disease across Asia and South America. In humans, infection is caused by variants of Trypanosoma brucei, and… read more here.
Keywords: disease caused; disease; african trypanosomes; virulence ... See more keywords
Stage-Specific COPII-Mediated Cargo Selectivity in African Trypanosomes
Sign Up to like & getrecommendations! Published in 2022 at "mSphere"
DOI: 10.1128/msphere.00188-22
Abstract: African trypanosomes synthesize dense surface coats composed of stage-specific glycosylphosphatidylinositol lipid anchored proteins. We previously defined specific machinery in bloodstream stage parasites that mediate the exit of these proteins from the endoplasmic reticulum. ABSTRACT A… read more here.
Keywords: stage specific; tbsec23 tbsec24; african trypanosomes; stage ... See more keywords
A DNA polymerization-independent role for mitochondrial DNA polymerase I-like protein C in African trypanosomes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cell Science"
DOI: 10.1242/jcs.233072
Abstract: ABSTRACT Mitochondrial DNA of Trypanosoma brucei and related parasites is a catenated network containing thousands of minicircles and tens of maxicircles, called kinetoplast DNA (kDNA). Replication of a single nucleoid requires at least three DNA… read more here.
Keywords: dna; dna polymerase; african trypanosomes; polymerase like ... See more keywords
The role of invariant surface glycoprotein 75 in xenobiotic acquisition by African trypanosomes
Sign Up to like & getrecommendations! Published in 2023 at "Microbial Cell"
DOI: 10.15698/mic2023.02.790
Abstract: The surface proteins of parasitic protozoa mediate functions essential to survival within a host, including nutrient accumulation, environmental sensing and immune evasion. Several receptors involved in nutrient uptake and defence from the innate immune response… read more here.
Keywords: suramin; invariant surface; african trypanosomes; surface ... See more keywords
Potent Antitrypanosomal Activities of 3-Aminosteroids against African Trypanosomes: Investigation of Cellular Effects and of Cross-Resistance with Existing Drugs
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24020268
Abstract: Treatment of animal African trypanosomiasis (AAT) requires urgent need for safe, potent and affordable drugs and this has necessitated this study. We investigated the trypanocidal activities and mode of action of selected 3-aminosteroids against Trypanosoma… read more here.
Keywords: potent antitrypanosomal; trypanosomes investigation; antitrypanosomal activities; activities aminosteroids ... See more keywords