Modeling antimalarial and antihuman African trypanosomiasis compounds: a ligand- and structure-based approaches
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Diversity"
DOI: 10.1007/s11030-019-10015-y
Abstract: Abstract This study examines the interaction of 137 antimalarial and antihuman African trypanosomiasis compounds [bis(2-aminoimidazolines), bisguanidinediphenyls and polyamines] on three different in vitro assays ( Trypanosoma brucei rhodesiense ( T . b . r .),… read more here.
Keywords: antimalarial antihuman; antihuman african; african trypanosomiasis; structure ... See more keywords
Factors influencing passive surveillance for T. b. rhodesiense human african trypanosomiasis in Uganda.
Sign Up to like & getrecommendations! Published in 2017 at "Acta tropica"
DOI: 10.1016/j.actatropica.2016.05.009
Abstract: INTRODUCTION Sleeping sickness or Human African Trypanosomiasis (HAT) is a neglected tropical disease of public health importance across much of Sub-Saharan Africa. In Uganda, chronic T. b. gambiense HAT (gHAT) and acute T. b. rhodesiense… read more here.
Keywords: trypanosomiasis; staff; surveillance; human african ... See more keywords
Human African Trypanosomiasis - A rare case report from India.
Sign Up to like & getrecommendations! Published in 2021 at "Indian journal of medical microbiology"
DOI: 10.1016/j.ijmmb.2021.06.012
Abstract: A young female patient from Ahmedabad city presented with acute febrile illness and bicytopenia (leukopenia and thrombocytopenia). She returned to India after recent visit to East Africa. Human African Trypanosomiasis (Sleeping sickness) was diagnosed by… read more here.
Keywords: trypanosomiasis rare; human african; case; african trypanosomiasis ... See more keywords
Melarsoprol Resistance in African Trypanosomiasis.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in parasitology"
DOI: 10.1016/j.pt.2018.04.002
Abstract: Arsenicals were introduced as monotherapies for the treatment of human African trypanosomiasis, or sleeping sickness, over 100 years ago. Toxicity has always been an issue but these drugs have proven to be both effective and… read more here.
Keywords: trypanosomiasis; drug; african trypanosomiasis; melarsoprol resistance ... See more keywords
Review of the Situation of Human African Trypanosomiasis in the Republic of Congo From the 1950s to 2020
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Entomology"
DOI: 10.1093/jme/tjab225
Abstract: Abstract Human African trypanosomiasis (HAT), despite considerable progress in the control, is still occurring in many countries in both west and central African regions. The HAT situation in the Republic of Congo has always been… read more here.
Keywords: human african; african trypanosomiasis; situation; republic congo ... See more keywords
A case of delayed diagnosis of East-African trypanosomiasis in a Dutch traveller.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of travel medicine"
DOI: 10.1093/jtm/tay024
Abstract: We present a case of East-African trypanosomiasis (EAT) in a 56-year-old Dutch woman returning from holiday in Tanzania and Kenya. The diagnosis was delayed due to the lack of suspicion and secondly because of postponed… read more here.
Keywords: trypanosomiasis; diagnosis; case; african trypanosomiasis ... See more keywords
Gambiense human African trypanosomiasis: the bumpy road to elimination
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Infectious Diseases"
DOI: 10.1097/qco.0000000000000860
Abstract: Purpose of review Gambiense human African trypanosomiasis (gHAT), a disease that has killed hundreds of thousands as recently as the 1990s, could be on the verge of elimination or even eradication. This review describes recent… read more here.
Keywords: gambiense human; african trypanosomiasis; elimination; human african ... See more keywords
A modelling assessment of short- and medium-term risks of programme interruptions for gambiense human African trypanosomiasis in the DRC
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Neglected Tropical Diseases"
DOI: 10.1101/2022.08.26.22279255
Abstract: Gambiense human African trypanosomiasis (gHAT) is a deadly vector-borne, neglected tropical disease found in West and Central Africa targeted for elimination of transmission (EoT) by 2030. The recent pandemic has illustrated how it can be… read more here.
Keywords: gambiense human; african trypanosomiasis; human african; interruption ... See more keywords
Integrating innovations: a qualitative analysis of referral non-completion among rapid diagnostic test-positive patients in Uganda’s human African trypanosomiasis elimination programme
Sign Up to like & getrecommendations! Published in 2018 at "Infectious Diseases of Poverty"
DOI: 10.1186/s40249-018-0472-x
Abstract: BackgroundThe recent development of rapid diagnostic tests (RDTs) for human African trypanosomiasis (HAT) enables elimination programmes to decentralise serological screening services to frontline health facilities. However, patients must still undertake multiple onwards referral steps to… read more here.
Keywords: microscopy; rapid diagnostic; human african; rdt ... See more keywords
Candidate gene polymorphisms study between human African trypanosomiasis clinical phenotypes in Guinea
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0005833
Abstract: Background Human African trypanosomiasis (HAT), a lethal disease induced by Trypanosoma brucei gambiense, has a range of clinical outcomes in its human host in West Africa: an acute form progressing rapidly to second stage, spontaneous… read more here.
Keywords: ci95; risk; human african; ci95 bonf ... See more keywords
Expression of interferon-inducible chemokines and sleep/wake changes during early encephalitis in experimental African trypanosomiasis
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0005854
Abstract: Background Human African trypanosomiasis or sleeping sickness, caused by the parasite Trypanosoma brucei, leads to neuroinflammation and characteristic sleep/wake alterations. The relationship between the onset of these alterations and the development of neuroinflammation is of… read more here.
Keywords: sleep wake; african trypanosomiasis; wake; brain ... See more keywords