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   Articles with "afterload" as a keyword



Effects of Red Blood Cell Sickling on Right Ventricular Afterload in vivo

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recommendations! Published in 2021 at "Experimental Mechanics"

DOI: 10.1007/s11340-020-00669-3

Abstract: Background Hemolysis in sickle cell disease (SCD) releases cell free hemoglobin, which scavenges nitric oxide (NO), leading to pulmonary vascular vasoconstriction, increased pulmonary vascular resistance (PVR), and the development of PH. However, PVR is only… read more here.

Keywords: red blood; afterload; cell free; free hemoglobin ... See more keywords
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Mechanoelectric coupling and arrhythmogenesis in cardiomyocytes contracting under mechanical afterload in a 3D viscoelastic hydrogel

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recommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2108484118

Abstract: Significance The heart autoregulates its contractile strength to maintain cardiac output when pumping blood against the mechanical afterload from vascular resistance. Increased afterload in cardiovascular diseases is associated with cardiac arrhythmias. However, the underlying mechanisms… read more here.

Keywords: afterload; mechanical afterload; ca2; viscoelastic hydrogel ... See more keywords

A novel nonlinear afterload for ex vivo heart evaluation: Porcine experimental results

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recommendations! Published in 2022 at "Artificial Organs"

DOI: 10.1111/aor.14307

Abstract: Abstract Background Existing working heart models for ex vivo functional evaluation of donor hearts often use cardiac afterloads made up of discrete resistive and compliant elements. This approach limits the practicality of independently controlling systolic… read more here.

Keywords: aortic pressure; pressure; heart; afterload vivo ... See more keywords

Detection of physiological control inputs preload and afterload from intrinsic pump parameters in total artificial heart.

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recommendations! Published in 2022 at "Artificial organs"

DOI: 10.1111/aor.14481

Abstract: BACKGROUND In the total artificial heart (TAH), the inputs to the physiological control unit, preload, and afterload, are detected from intrinsic pump parameters (e.g., motor current). Within this study, their detection techniques are developed, and… read more here.

Keywords: preload afterload; total artificial; heart; preload ... See more keywords

The Arterial Load and Right Ventricular-Vascular Coupling in Pulmonary Hypertension.

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recommendations! Published in 2021 at "Journal of applied physiology"

DOI: 10.1152/japplphysiol.00204.2021

Abstract: Right ventricular (RV) functional adaptation to afterload determines outcome in pulmonary hypertension (PH). RV afterload is determined by the dynamic interaction between pulmonary vascular resistance (PVR), characteristic impedance (Zc) and wave reflection. Zc and wave… read more here.

Keywords: pulmonary hypertension; afterload; right ventricular; hypertension ... See more keywords

Pulmonary vascular collagen content, not cross-linking, contributes to right ventricular pulsatile afterload and overload in early pulmonary hypertension.

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recommendations! Published in 2017 at "Journal of applied physiology"

DOI: 10.1152/japplphysiol.00325.2016

Abstract: Hypoxic pulmonary hypertension (HPH) is associated with pulmonary artery (PA) remodeling and right ventricular (RV) overload. We have previously uncovered collagen-mediated mechanisms of proximal PA stiffening in early HPH by manipulating collagen degradation and cross-linking… read more here.

Keywords: collagen; collagen content; cross linking; afterload ... See more keywords

An Unwelcome Embrace: Adverse Pulmonary-Aortic Interactions in Pulmonary Hypertension.

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recommendations! Published in 2017 at "Circulation. Cardiovascular imaging"

DOI: 10.1161/circimaging.117.006063

Abstract: Vascular remodeling in pulmonary hypertension (PH) causes increased ventricular afterload, resulting in right ventricular failure and high mortality.1 Afterload is the mechanical impedance imposed by the arterial tree, against which the ventricle must work to… read more here.

Keywords: ventricular afterload; pulmonary hypertension; unwelcome embrace; afterload ... See more keywords

Effect of Balloon Pulmonary Angioplasty and Riociguat on Right Ventricular Afterload and Function in CTEPH: Insights From the RACE Trial

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recommendations! Published in 2025 at "Circulation: Cardiovascular Interventions"

DOI: 10.1161/circinterventions.124.014785

Abstract: BACKGROUND: Riociguat and balloon pulmonary angioplasty (BPA) improve hemodynamics in inoperable chronic thromboembolic pulmonary hypertension. Importantly, comparative effects of riociguat and BPA on different components of right ventricular (RV) afterload and function remain not fully… read more here.

Keywords: riociguat; pulmonary angioplasty; bpa; afterload ... See more keywords

Afterload Mismatch Is Associated With Higher Cardiac Mortality After Heart Transplantation.

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recommendations! Published in 2025 at "Journal of the American Heart Association"

DOI: 10.1161/jaha.124.040636

Abstract: Background Heart transplant (HT) recipients tend to develop unfavorable ventricular–arterial interactions, yet the prognostic implications of this altered physiology remain unclear. We aimed to identify the presence of afterload mismatch (AM) after heart transplantation, its… read more here.

Keywords: cardiac mortality; afterload; heart; mortality ... See more keywords

Sex differences in left ventricular afterload and diastolic function are independent from the aortic size

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recommendations! Published in 2019 at "PLoS ONE"

DOI: 10.1371/journal.pone.0214907

Abstract: Background Women have a greater risk of heart failure with preserved ejection fraction (HFPEF) than men do, yet the basis for this disparity remains unclear. Greater arterial stiffness and afterload causes left ventricular (LV) diastolic… read more here.

Keywords: afterload; sex differences; size; sex ... See more keywords

Afterload reduction after non-invasive vagus nerve stimulation in acute heart failure

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recommendations! Published in 2023 at "Frontiers in Human Neuroscience"

DOI: 10.3389/fnhum.2023.1149449

Abstract: Introduction While central blood pressure (BP) has been recognized as a major indicator of left ventricular (LV) afterload, the reduction of central pressure decreases LV afterload and may prevent heart failure (HF) decompensation. Non-invasive transcutaneous… read more here.

Keywords: non invasive; afterload reduction; stimulation; heart ... See more keywords